Feedback loops shape cellular signals in space and time

被引：345

作者：

Brandman, Onn ^{[1
,2
]}

Meyer, Tobias ^{[3
]}

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

[2] Howard Hughes Med Inst, San Francisco, CA 94158 USA

[3] Stanford Univ, Med Ctr, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

SCIENCE | 2008年 / 322卷 / 5900期

关键词：

D O I：

10.1126/science.1160617

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.

引用

页码：390 / 395

页数：6

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