Cellular uptake and cytotoxicity of silica nanotubes

被引：187

作者：

Nan, Anjan ^{[1
,2
]}

Bai, Xia ^{[3
]}

Son, Sang Jun ^{[3
,5
]}

Lee, Sang Bok ^{[1
,3
,4
]}

Ghandehari, Hamidreza ^{[1
,2
,4
]}

机构：

[1] Univ Maryland, Ctr Nanomed & Cellular Delivery, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[3] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[4] Univ Maryland, Maryland NanoCtr, College Pk, MD 20742 USA

[5] Kyungwon Univ, Gachon BioNano Res Inst, Songnam, Gyeonggi Do, South Korea

来源：

NANO LETTERS | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1021/nl0802741

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Template synthesized silica nanotubes (SNTs) provide unique features such as end functionalization to control drug release, inner voids for loading biomolecules, and distinctive inner and outer surfaces that can be differentially functionalized for targeting and biocompatibility. Very limited information is available about their biological interactions. This work evaluates the influence of size and surface charge of SNTs on cellular toxicity and uptake. Results additionally indicate endocylosis to be one possible mechanism of internalization of SNTs.

引用

页码：2150 / 2154

页数：5

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