Epigenetics of Colorectal Cancer

被引：253

作者：

Goel, Ajay

Boland, C. Richard

机构：

[1] Baylor Univ, Med Ctr, Gastrointestinal Canc Res Lab, Div Gastroenterol,Dept Internal Med,Sammons Canc, Dallas, TX 75246 USA

[2] Baylor Univ, Med Ctr, Baylor Res Inst, Dallas, TX 75246 USA

来源：

GASTROENTEROLOGY | 2012年 / 143卷 / 06期

基金：

美国国家卫生研究院;

关键词：

microRNA; DNA Methylation; Histone Modifications; Genomic Instability; ISLAND METHYLATOR PHENOTYPE; MICROSATELLITE-INSTABILITY STATUS; HMLH1 PROMOTER HYPERMETHYLATION; HISTONE DEACETYLASE INHIBITORS; ADENOMATOUS POLYPOSIS-COLI; SESSILE SERRATED ADENOMAS; DNA METHYLTRANSFERASES 3A; TUMOR-SUPPRESSOR GENES; MICRORNA EXPRESSION; MISMATCH REPAIR;

D O I：

10.1053/j.gastro.2012.09.032

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

In the early years of the molecular biology revolution, cancer research was mainly focused on genetic changes (ie, those that altered DNA sequences). Although this has been extremely useful as our understanding of the pathogenesis and biology of cancer has grown and matured, there is another realm in tumor development that does not involve changing the sequence of cellular DNA. This field is called "epigenetics" and broadly encompasses changes in the methylation of cytosines in DNA, changes in histone and chromatin structure, and alterations in the expression of microRNAs, which control the stability of many messenger RNAs and serve as "master regulators" of gene expression. This review focuses on the epigenetics of colorectal cancer and illustrates the impact epigenetics has had on this field.

引用

页码：1442 / +

页数：20

共 199 条

[1]

Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas [J].

Ahlquist, David A. ;

Zou, Hongzhi ;

Domanico, Michael ;

Mahoney, Douglas W. ;

Yab, Tracy C. ;

Taylor, William R. ;

Butz, Malinda L. ;

Thibodeau, Stephen N. ;

Rabeneck, Linda ;

Paszat, Lawrence F. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Bjerregaard, Niels Chr. ;

Laurberg, Soren ;

Sorensen, Henrik Toft ;

Berger, Barry M. ;

Lidgard, Graham P. .

GASTROENTEROLOGY, 2012, 142 (02) :248-256

[2]

Ahuja N, 1998, CANCER RES, V58, P5489

[3]

Ahuja N, 2000, HISTOL HISTOPATHOL, V15, P835, DOI 10.14670/HH-15.835

[4]

MicroRNA-143 and-145 in colon cancer [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Naoe, Tomoki .

DNA AND CELL BIOLOGY, 2007, 26 (05) :311-320

[5]

miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer [J].

Akcakaya, Pinar ;

Ekelund, Susanne ;

Kolosenko, Iryna ;

Caramuta, Stefano ;

Ozata, Deniz M. ;

Xie, Hong ;

Lindforss, Ulrik ;

Olivecrona, Hans ;

Lui, Weng-Onn .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 39 (02) :311-318

[6]

Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer [J].

Arndt, Greg M. ;

Dossey, Lesley ;

Cullen, Lara M. ;

Lai, Angela ;

Druker, Riki ;

Eisbacher, Michael ;

Zhang, Chunyan ;

Tran, Nham ;

Fan, Hongtao ;

Retzlaff, Kathy ;

Bittner, Anton ;

Raponi, Mitch .

BMC CANCER, 2009, 9 :374

[7]

Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines [J].

Arnold, CN ;

Goel, A ;

Boland, CR .

INTERNATIONAL JOURNAL OF CANCER, 2003, 106 (01) :66-73

[8]

APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q [J].

Arnold, CN ;

Goel, A ;

Niediwiecki, D ;

Dowell, JM ;

Wasserman, L ;

Compton, C ;

Mayer, RJ ;

Bertagnolli, MM ;

Boland, CR .

CANCER BIOLOGY & THERAPY, 2004, 3 (10) :960-964

[9]

Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer [J].

Arnold, CN ;

Goel, A ;

Compton, C ;

Marcus, V ;

Niedzwiecki, D ;

Dowell, JM ;

Wasserman, L ;

Inoue, T ;

Mayer, RJ ;

Bertagnolli, MM ;

Boland, CR .

CANCER BIOLOGY & THERAPY, 2004, 3 (01) :73-78

[10]

Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and Carcinoma [J].

Ashktorab, Hassan ;

Belgrave, Kevin ;

Hosseinkhah, Fatemeh ;

Brim, Hassan ;

Nouraie, Mehdi ;

Takkikto, Mikiko ;

Hewitt, Steve ;

Lee, Edward L. ;

Dashwood, R. H. ;

Smoot, Duane .

DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (10) :2109-2117

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