Distributed representation of spectral and temporal information in rat primary auditory cortex

被引:114
作者
Kilgard, MP
Merzenich, MM
机构
[1] Univ Calif San Francisco, Keck Ctr Integrat Neurosci, Coleman Lab, Dept Otolaryngol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Keck Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
[3] Sci Learning Corp, Berkeley, CA 94104 USA
关键词
auditory cortex; cerebral cortex; tonotopic map; temporal processing; repetition rate transfer function; rat;
D O I
10.1016/S0378-5955(99)00061-1
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Modulations of amplitude and frequency ae common features of natural sounds, and are prominent in behaviorally important communication sounds. The mammalian auditory cortex is known to contain representations of these important stimulus parameters. This study describes the distributed representations of tone frequency and modulation rate in the rate primary auditory cortex (Al). Detailed maps of auditory cortex responses to single tones and tone trains were constructed from recordings from 50-60 microelectrode penetrations introduced into each hemisphere. Recorded data demonstrated that the cortex uses a distributed coding strategy to represent both spectral and temporal information in the rat, as in other species. Just as spectral information is encoded in the firing patterns of neurons tuned to different frequencies, temporal information appears to be encoded using a set of filters covering a range of behaviorally important repetition rates. Although the average Al repetition rate transfer function (RRTF) was low-pass with a sharp drop-off in evoked spikes per tone above 9 pules per second (pps), individual RRTFs exhibited significant structure between 4 and 10 pps, including substantial facilitation or depression to tones presented at specific rates. No organized topography of these temporal filters could be determined. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:16 / 28
页数:13
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