Parent of Origin Effects in Attention/Deficit Hyperactivity Disorder (ADHD): Analysis of Data From the International Multicenter ADHD Genetics (IMAGE) Program

被引：23

作者：

Anney, Richard J. L. ^{[1
]}

Hawi, Ziarih

Sheehan, Karen

Mulligan, Aisling

Pinto, Carlos

Brookes, Keeley J. ^{[2
]}

Xu, Xiaohui ^{[2
]}

Zhou, Kaixin ^{[2
]}

Franke, Barbara ^{[3
,4
]}

Buitelaar, Jan ^{[3
]}

Vermeulen, Sita H. ^{[4
,5
]}

Banaschewski, Tobias ^{[6
]}

Sonuga-Barke, Edmund J. S. ^{[8
]}

Ebstein, Richard ^{[9
]}

Manor, Iris ^{[10
]}

Miranda, Ana ^{[11
]}

Mulas, Fernando ^{[11
]}

Oades, Robert D. ^{[12
]}

Roeyers, Herbert ^{[13
]}

Rommelse, Nanda ^{[14
]}

Rothenberger, Aribert ^{[7
]}

Sergeant, Joseph ^{[14
]}

Steinhausen, Hans-Christoph ^{[15
]}

Taylor, Eric ^{[2
]}

Thompson, Margaret ^{[8
]}

Asherson, Philip ^{[2
]}

Faraone, Stephen V. ^{[16
,17
]}

Gill, Michael

机构：

[1] St James Hosp, Trinity Coll Dublin, Trinity Ctr Hlth Sci, Dept Psychiat,Neuropsychiat Genet Res Grp, Dublin 8, Ireland

[2] Inst Psychiat, MRC, Social Genet Dev & Psychiat Ctr, London, England

[3] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol & Biostat, NL-6525 ED Nijmegen, Netherlands

[6] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-6800 Mannheim, Germany

[7] Univ Gottingen, Gottingen, Germany

[8] Univ Southampton, Sch Psychol, Southampton, Hants, England

[9] S Herzog Mem Hosp, Jerusalem, Israel

[10] Geha Mental Hlth Ctr, ADHD Clin, Petah Tiqwa, Israel

[11] Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain

[12] Univ Clin Child & Adolescent Psychiat, Essen, Germany

[13] Univ Ghent, Dept Expt Clin Hlth Psychol, B-9000 Ghent, Belgium

[14] Vrije Univ Amsterdam, Amsterdam, Netherlands

[15] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland

[16] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA

[17] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2008年 / 147B卷 / 08期

关键词：

ADHD; candidate gene; parent of origin effect;

D O I：

10.1002/ajmg.b.30659

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and genespecific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (chi(2)(1) = 1.82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD. (c) 2007 Wiley-Liss, Inc.

引用

页码：1495 / 1500

页数：6

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