Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

被引：20

作者：

Hasegawa, T

Umeda, M

Matsumoto, T

Numata, M

Mizu, M

Koumoto, K

Sakurai, K

Shinkai, S

机构：

[1] Kyushu Univ, Grad Sch Engn, Dept Chem & Biotechnol, Higashi Ku, Fukuoka 8128581, Japan

[2] Univ Kitakyushu, Fac Environm Engn, Dept Chem Proc & Environm, Wakamatsu Ku, Fukuoka 8080135, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 04期

关键词：

D O I：

10.1039/b313426a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A schizophyllan (beta-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

引用

收藏

页码：382 / 383

页数：2

相关论文

共 22 条

[1] Melting behaviour of schizophyllan extracellular polysaccharide gels in the temperature range between 5 and 20°C [J].

Bot, A ;

Smorenburg, HE ;

Vreeker, R ;

Pâques, M ;

Clark, AH .

CARBOHYDRATE POLYMERS, 2001, 45 (04) :363-372

[2] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[3] The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides [J].

Chirila, TV ;

Rakoczy, PE ;

Garrett, KL ;

Lou, X ;

Constable, IJ .

BIOMATERIALS, 2002, 23 (02) :321-342

[4] PACKING ANALYSIS OF CARBOHYDRATES AND POLYSACCHARIDES .14. TRIPLE-HELICAL CRYSTALLINE-STRUCTURE OF CURDLAN AND PARAMYLON HYDRATES [J].

CHUAH, CT ;

SARKO, A ;

DESLANDES, Y ;

MARCHESSAULT, RH .

MACROMOLECULES, 1983, 16 (08) :1375-1382

[5] A C-MYB ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS NORMAL HUMAN HEMATOPOIESIS INVITRO [J].

GEWIRTZ, AM ;

CALABRETTA, B .

SCIENCE, 1988, 242 (4883) :1303-1306

[6] Rigid helical poly(glycosyl phenyl isocyanide)s: Synthesis, conformational analysis, and recognition by lectins [J].

Hasegawa, T ;

Kondoh, S ;

Matsuura, K ;

Kobayashi, K .

MACROMOLECULES, 1999, 32 (20) :6595-6603

[7] A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides [J].

Jääskeläinen, I ;

Peltola, S ;

Honkakoski, P ;

Mönkkönen, J ;

Urtti, A .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2000, 10 (03) :187-193

[8] Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline [J].

Kataoka, K ;

Togawa, H ;

Harada, A ;

Yasugi, K ;

Matsumoto, T ;

Katayose, S .

MACROMOLECULES, 1996, 29 (26) :8556-8557

[9] Gene therapy of cystic fibrosis (CF) airways: A review emphasizing targeting with lactose [J].

Klink, DT ;

Glick, MC ;

Scanlin, TF .

GLYCOCONJUGATE JOURNAL, 2001, 18 (09) :731-740

[10] Polysaccharide-polynucleotide complexes (IV): Antihydrolysis effect of the schizophyllan/poly(C) complex and the complex dissociation induced by amines [J].

Koumoto, K ;

Kimura, T ;

Sakurai, K ;

Shinkai, S .

BIOORGANIC CHEMISTRY, 2001, 29 (03) :178-185