Fluoromethcathinone, a new substance of abuse

被引:110
作者
Archer, R. P. [1 ]
机构
[1] Kingston Univ, Kingston upon Thames KT1 2EE, Surrey, England
关键词
Fluoromethcathinone; Flephedrone; (19)F NMR; FTIR; GC-MS; Positional isomers; DESIGNER DRUGS; METHCATHINONE; INHIBITION; ISOMERS;
D O I
10.1016/j.forsciint.2008.11.013
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
We have identified a new compound in capsules marketed as plant feeders available from internet suppliers. It is apparent from internet forums that these so-called plant feeders are being used as recreational drugs. The material is identified as being 3'-fluoromethcathinone. The compound in the capsule was identified by GC-MS, I H, (13)C and (19)F NMR as well as FTIR. Other materials identified in the tablet were caffeine and a methylamine salt. The exact position of the fluorine in the fluoromethcathinone was determined by comparison with materials synthesised in our laboratory. Internet-based companies are known to sell 4'-fluoromethcathinone (flephedrone). We present GC-MS data for the three isomers of fluoromethcathinone and their N-acetyl derivatives and provide a rapid method for determining the positional isomers of fluoromethcathinone using FTIR or (19)F NMR. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:10 / 20
页数:11
相关论文
共 12 条
[1]  
ARCHER R, UNPUB
[2]   Chromatographic and mass spectral studies on methoxymethcathinones related to 3,4-methylenedioxymethamphetamine [J].
Awad, T ;
Clark, CR ;
DeRuiter, J .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2006, 44 (03) :155-161
[3]   Methcathinone: A new postindustrial drug [J].
Belhadj-Tahar, H ;
Sadeg, N .
FORENSIC SCIENCE INTERNATIONAL, 2005, 153 (01) :99-101
[4]   THE SYNTHESIS AND SPECTRA OF 4-ETHOXYAMPHETAMINE AND ITS ISOMERS [J].
BY, AW ;
DUHAIME, R ;
LODGE, BA .
FORENSIC SCIENCE INTERNATIONAL, 1991, 49 (02) :159-170
[5]   Inhibition of plasma membrane monoamine transporters by β-ketoamphetamines [J].
Cozzi, NV ;
Sievert, MK ;
Shulgin, AT ;
Jacob, P ;
Ruoho, AE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 381 (01) :63-69
[6]   A re-examination of the mono-methoxy positional ring isomers of amphetamine, methamphetamine and phenyl-2-propanone [J].
Dal Cason, TA .
FORENSIC SCIENCE INTERNATIONAL, 2001, 119 (02) :168-194
[7]   METHCATHINONE (CAT) - AN ENANTIOMERIC POTENCY COMPARISON [J].
GLENNON, RA ;
YOUNG, R ;
MARTIN, BR ;
DALCASON, TA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 50 (04) :601-606
[8]  
KING L, 2003, MISUSE DRUGS ACT GUI, P63
[9]   MAO inhibition by arylisopropylamines:: the effect of oxygen substituents at the β-position [J].
Osorio-Olivares, M ;
Rezende, MC ;
Sepúlveda-Boza, S ;
Cassels, BK ;
Fierro, A .
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (15) :4055-4066
[10]   A two-step method for the preparation of homochiral cathinones [J].
Osorio-Olivares, M ;
Rezende, MC ;
Sepúlveda-Boza, S ;
Cassels, BK ;
Baggio, RF ;
Muñoz-Acevedo, JC .
TETRAHEDRON-ASYMMETRY, 2003, 14 (11) :1473-1477