Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis

被引：41

作者：

Nakashima, T ^{[1
]}

Sumida, Y

Furutani, M

Hirohama, A

Okita, M

Mitsuyoshi, H

Itoh, Y

Okanoue, T

机构：

[1] Saiseikai Kyoto Hosp, Dept Internal Med, Kyoto 6170814, Japan

[2] Nara City Hosp, Dept Internal Med, Nara 6308305, Japan

[3] Kyoto Prefectural Univ, Dept Mol Gastroenterol & Hepatol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

HEPATOLOGY RESEARCH | 2005年 / 33卷 / 02期

关键词：

thioredoxin; oxidative stress; ferritin; steatohepatitis;

D O I：

10.1016/j.hepres.2005.09.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Thioredoxin (TRX) is induced by many oxidative stresses. Serum TRX levels were significantly elevated in nonalcoholic steatohepatitis (NASH) patients, as compared to simple fatty liver (FL) patients or healthy controls. Serum TRX levels in NASH patients were significantly correlated with serum ferritin levels, but not with other variables. Removal of hepatic excess iron by phlebotomy significantly decreased the serum levels of TRX and ALT in NASH patient. Therefore, the pathogenesis of NASH may be associated with iron-related oxidative stress. The serum TRX level is a parameter for discriminating NASH from FL. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：135 / 137

页数：3

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