Elimination reactions of (E)- and (Z)-benzaldehyde O-pivaloyloximes. Transition-state differences for the syn and anti eliminations forming nitriles

Elimination reactions of(E)- and (Z)-benzaldehyde O-pivaloyloximes 1 and 2 with. DBU in MeCN have been investigated kinetically. The reactions are second order and exhibit substantial values of Hammett rho and k(H)/k(D) values, and an E2 mechanism is evident. The rate of elimination from 2 is approximately 20 000-fold faster than that from 1. For reactions of 9 with DBU in MeCN, a Hammett rho value of 2.4 +/- 0.1, k(H)/k(D) = 2.7 +/- 0.3, Delta H-double dagger = 12.5 +/- 0.2 kcal/mol, and Delta S-double dagger = -31.0 +/- 0.6 eu have been determined. The corresponding values for 2 are rho = 1.4, +/- 0.1, k(H)/k(D) = 7.8 +/- 0.3, Delta H-double dagger = 8.8 +/- 0.1 kcal/mol, and Delta S-double dagger = -23.6 +/- 0.4 eu, respectively. The results indicate that the nitrile-forming anti eliminations from 2 proceed via a more symmetrical transition state with a smaller degree of proton transfer, less negative charge development at the beta-carbon, and greater extent of triple-bond formation than that for the syn elimination.