Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

被引：130

作者：

Fuster-Matanzo, Almudena ^{[1
,2
]}

Llorens-Martin, Maria ^{[1
,2
]}

Hernandez, Felix ^{[1
,2
]}

Avila, Jesus ^{[1
,2
]}

机构：

[1] UAM, CSIC, Ctr Biol Mol Severo Ochoa, Dept Mol Neurobiol, Madrid, Spain

[2] ISCIII, CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031, Spain

来源：

MEDIATORS OF INFLAMMATION | 2013年 / 2013卷

关键词：

AMYLOID PRECURSOR PROTEIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CENTRAL-NERVOUS-SYSTEM; PROGRAMMED CELL-DEATH; HIPPOCAMPAL NEUROGENESIS; MICROGLIAL ACTIVATION; NEURODEGENERATIVE DISEASES; INFLAMMATORY CYTOKINES; COGNITIVE DECLINE; TRANSGENIC MICE;

D O I：

10.1155/2013/260925

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field.

引用

页数：9

共 109 条

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