Mitosis: MCAK under the aura of Aurora B

被引：43

作者：

Gorbsky, GJ ^{[1
]}

机构：

[1] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 09期

关键词：

D O I：

10.1016/j.cub.2004.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two new studies show that phosphorylation by Aurora B kinase controls the centromere localization and catalytic activity of the microtubule depolymerase MCAK. Physical tension from microtubule attachment may influence access of MCAK to Aurora B kinase and its opposing phosphatases.

引用

收藏

页码：R346 / R348

页数：3

相关论文

共 17 条

[1]

Differential subcellular localization of protein phosphatase-1 α, γ1, and δ isoforms during both interphase and mitosis in mammalian cells [J].

Andreassen, PR ;

Lacroix, FB ;

Villa-Moruzzi, E ;

Margolis, RL .

JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1207-1215

[2]

Aurora B regulates MCAK at the mitotic centromere [J].

Andrews, PD ;

Ovechkina, Y ;

Morrice, N ;

Wagenbach, M ;

Duncan, K ;

Wordeman, L ;

Swedlow, JR .

DEVELOPMENTAL CELL, 2004, 6 (02) :253-268

[3]

The cellular geography of aurora kinases [J].

Carmena, M ;

Earnshaw, WC .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (11) :842-854

[4]

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint [J].

Hauf, S ;

Cole, RW ;

LaTerra, S ;

Zimmer, C ;

Schnapp, G ;

Walter, R ;

Heckel, A ;

van Meel, J ;

Rieder, CL ;

Peters, JM .

JOURNAL OF CELL BIOLOGY, 2003, 161 (02) :281-294

[5]

Mitotic phosphorylation of histone H3 is governed by IpI1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes [J].

Hsu, JY ;

Sun, ZW ;

Li, XM ;

Reuben, M ;

Tatchell, K ;

Bishop, DK ;

Grushcow, JM ;

Brame, CJ ;

Caldwell, JA ;

Hunt, DF ;

Lin, RL ;

Smith, MM ;

Allis, CD .

CELL, 2000, 102 (03) :279-291

[6]

Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis [J].

Kallio, MJ ;

McCleland, ML ;

Stukenberg, PT ;

Gorbsky, GJ .

CURRENT BIOLOGY, 2002, 12 (11) :900-905

[7]

Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments [J].

Kline-Smith, SL ;

Khodjakov, A ;

Hergert, P ;

Walczak, CE .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (03) :1146-1159

[8]

The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells [J].

Kline-Smith, SL ;

Walczak, CE .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (08) :2718-2731

[9]

Correcting improper chromosome-spindle attachments during cell division [J].

Lampson, MA ;

Renduchitala, K ;

Khodjakov, A ;

Kapoor, TM .

NATURE CELL BIOLOGY, 2004, 6 (03) :232-237

[10]

Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity [J].

Lan, WJ ;

Zhang, X ;

Kline-Smith, SL ;

Rosasco, SE ;

Barrett-Wilt, GA ;

Shabanowitz, J ;

Walczak, CE ;

Stukenberg, PT .

CURRENT BIOLOGY, 2004, 14 (04) :273-286