Plasma ropivacaine levels following scalp block for awake craniotomy

被引：42

作者：

Costello, TG ^{[1
]}

Cormack, JR ^{[1
]}

Hoy, C ^{[1
]}

Wyss, A ^{[1
]}

Braniff, V ^{[1
]}

Martin, K ^{[1
]}

Murphy, M ^{[1
]}

机构：

[1] St Vincents Hosp, Melbourne, Vic, Australia

来源：

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY | 2004年 / 16卷 / 02期

关键词：

ropivacaine; scalp blockade; awake craniotomy; toxicity;

D O I：

10.1097/00008506-200404000-00007

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The plasma levels of ropivacaine HCl with 5 mcg/mL epinephrine were measured in 10 patients following scalp blockade for awake craniotomy. A mean dose of 260 mg (3.6 mg/kg) resulted in peak plasma concentrations of 1.5 +/- 0.6 mcg/mL, with a median time to peak plasma concentration of 15 minutes. The pattern of rise of plasma level was similar in all patients and rapid compared with other regional blocks (epidural, intercostal, and axillary brachial plexus block). Despite this rapid rise of plasma level, no signs of cardiovascular or central nervous system toxicity were observed. In this group of patients undergoing awake craniotomy for excision of lesions in the eloquent areas of the cerebral cortex, ropivacaine HCl with epinephrine appeared to be a safe and effective local anesthetic agent in the dosages used.

引用

页码：147 / 150

页数：4

共 24 条

[1] PRIMARY EVALUATION OF THE LOCAL-ANESTHETIC PROPERTIES OF THE AMINO AMIDE AGENT ROPIVACAINE (LEA-103) [J].