Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop

被引：154

作者：

Bikson, Marom ^{[1
]}

Brunoni, Andre R. ^{[2
]}

Charvet, Leigh E. ^{[3
]}

Clark, Vincent P. ^{[4
]}

Cohen, Leonardo G. ^{[5
]}

Deng, Zhi-De ^{[6
,7
]}

Dmochowski, Jacek ^{[1
]}

Edwards, Dylan J. ^{[8
]}

Frohlich, Flavio ^{[9
]}

Kappenman, Emily S. ^{[10
]}

Lim, Kelvin O. ^{[11
,12
]}

Loo, Colleen ^{[13
,14
]}

Mantovani, Antonio ^{[15
]}

McMullen, David P. ^{[16
]}

Parra, Lucas C. ^{[1
]}

Pearson, Michele ^{[16
]}

Richardson, Jessica D. ^{[17
]}

Rumsey, Judith M. ^{[16
]}

Sehatpour, Pejman ^{[18
]}

Sommers, David ^{[19
]}

Unal, Gozde ^{[1
]}

Wassermann, Eric M. ^{[20
]}

Woods, Adam J. ^{[21
]}

Lisanby, Sarah H. ^{[15
,16
]}

机构：

[1] CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA

[2] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil

[3] NYU, Sch Med, Dept Neurol, New York, NY USA

[4] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA

[5] NINDS, Human Cort Physiol & Neurorehabil Sect, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[6] NIMH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 USA

[7] Burke Cornell Med Res Facil, Burke Rehabil & Res, Noninvas Brain Stimulat & Human Motor Control Lab, White Plains, NY USA

[8] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia

[9] Univ N Carolina, Sch Med, Carolina Ctr Neurostimulat, Dept Psychiat Cell Biol & Physiol,Biomed Engn & N, Chapel Hill, NC USA

[10] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA

[11] Univ Minnesota, Dept Psychiat, Minneapolis Vet Adm Hlth Care Syst, Minneapolis, MN 55455 USA

[12] Def Vet Brain Injury Ctr, Minneapolis, MN USA

[13] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[14] Univ New South Wales, Black Dog Inst, Sydney, NSW, Australia

[15] CUNY City Coll, Dept Physiol Pharmacol & Neurosci, New York, NY 10031 USA

[16] NIMH, Div Translat Res, Bethesda, MD 20892 USA

[17] Univ New Mexico, Dept Speech & Hearing Sci, Albuquerque, NM 87131 USA

[18] Columbia Univ, Dept Psychiat, New York, NY USA

[19] NIMH, Sci Review Branch, Bethesda, MD 20892 USA

[20] NINDS, Behav Neurol Unit, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[21] Univ Florida, Dept Clin & Hlth Psychol, Ctr Cognit Aging & Memory, McKnight Brain Inst, Gainesville, FL USA

来源：

BRAIN STIMULATION | 2018年 / 11卷 / 03期

关键词：

Neuromodulation Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS); Transcranial electrical stimulation (tES); Reproducibility; RANDOMIZED CONTROLLED-TRIAL; HUMAN MOTOR CORTEX; COMPUTATIONAL MODELS; HD-TDCS; MAGNETIC STIMULATION; BRAIN-STIMULATION; CURRENT THERAPY; WORKING-MEMORY; DOUBLE-BLIND; CORTICAL OSCILLATIONS;

D O I：

10.1016/j.brs.2017.12.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Neuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of increasing interest given their potential for manipulating circuits directly. Low intensity transcranial electrical stimulation (tES) with direct currents (transcranial direct current stimulation, tDCS) or alternating currents (transcranial alternating current stimulation, tACS) represent novel, safe, well- tolerated, and relatively inexpensive putative treatment modalities. Objective: This report seeks to promote the science, technology and effective clinical applications of these modalities, identify research challenges, and suggest approaches for addressing these needs in order to achieve rigorous, reproducible findings that can advance clinical treatment. Methods: The National Institute of Mental Health (NIMH) convened a workshop in September 2016 that brought together experts in basic and human neuroscience, electrical stimulation biophysics and devices, and clinical trial methods to examine the physiological mechanisms underlying tDCS/tACS, technologies and technical strategies for optimizing stimulation protocols, and the state of the science with respect to therapeutic applications and trial designs.

引用

页码：465 / 480

页数：16

共 191 条

[1]

Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent [J].

Alagapan, Sankaraleengam ;

Schmidt, Stephen L. ;

Lefebvre, Jeremie ;

Hadar, Eldad ;

Shin, Hae Won ;

Froehlich, Flavio .

PLOS BIOLOGY, 2016, 14 (03)

[2]

Transcranial Alternating Current Stimulation Modulates Large-Scale Cortical Network Activity by Network Resonance [J].

Ali, Mohsin M. ;

Sellers, Kristin K. ;

Frohlich, Flavio .

JOURNAL OF NEUROSCIENCE, 2013, 33 (27) :11262-11275

[3]

Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke [J].

Allman, Claire ;

Amadi, Ugwechi ;

Winkler, Anderson M. ;

Wilkins, Leigh ;

Filippini, Nicola ;

Kischka, Udo ;

Stagg, Charlotte J. ;

Johansen-Berg, Heidi .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (330)

[4]

Study design and methodology for a multicentre, randomised controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression [J].

Alonzo, Angelo ;

Aaronson, Scott ;

Bikson, Marom ;

Husain, Mustafa ;

Lisanby, Sarah ;

Martin, Donel ;

McClintock, Shawn M. ;

McDonald, William M. ;

O'Reardon, John ;

Esmailpoor, Zeinab ;

Loo, Colleen .

CONTEMPORARY CLINICAL TRIALS, 2016, 51 :65-71

[5]

Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines [J].

Antal, A. ;

Alekseichuk, I. ;

Bikson, M. ;

Brockmoeller, J. ;

Brunoni, A. R. ;

Chen, R. ;

Cohen, L. G. ;

Dowthwaite, G. ;

Ellrich, J. ;

Floeel, A. ;

Fregni, F. ;

George, M. S. ;

Hamilton, R. ;

Haueisen, J. ;

Herrmann, C. S. ;

Hummel, F. C. ;

Lefaucheur, J. P. ;

Liebetanz, D. ;

Loo, C. K. ;

McCaig, C. D. ;

Miniussi, C. ;

Miranda, P. C. ;

Moliadze, V. ;

Nitsche, M. A. ;

Nowak, R. ;

Padberg, F. ;

Pascual-Leone, A. ;

Poppendieck, W. ;

Priori, A. ;

Rossi, S. ;

Rossini, P. M. ;

Rothwell, J. ;

Rueger, M. A. ;

Ruffini, G. ;

Schellhorn, K. ;

Siebner, H. R. ;

Ugawa, Y. ;

Wexler, A. ;

Ziemann, U. ;

Hallett, M. ;

Paulus, W. .

CLINICAL NEUROPHYSIOLOGY, 2017, 128 (09) :1774-1809

[6]

A Systematic Review on the Acceptability and Tolerability of Transcranial Direct Current Stimulation Treatment in Neuropsychiatry Trials [J].

Aparicio, Luana V. M. ;

Guarienti, Fabiana ;

Razza, Lais Boralli ;

Carvalho, Andre F. ;

Fregni, Felipe ;

Brunoni, Andre Russowsky .

BRAIN STIMULATION, 2016, 9 (05) :671-681

[7]

Computational models of Bitemporal, Bifrontal and Right Unilateral ECT predict differential stimulation of brain regions associated with efficacy and cognitive side effects [J].

Bai, S. ;

Galvez, V. ;

Dokos, S. ;

Martin, D. ;

Bikson, M. ;

Loo, C. .

EUROPEAN PSYCHIATRY, 2017, 41 :21-29

[8]

Common Measures for National Institute of Mental Health Funded Research [J].

Barch, Deanna M. ;

Gotlib, Ian H. ;

Bilder, Robert M. ;

Pine, Daniel S. ;

Smoller, Jordan W. ;

Brown, C. Hendricks ;

Huggins, Wayne ;

Hamilton, Carol ;

Haim, Adam ;

Farber, Gregory K. .

BIOLOGICAL PSYCHIATRY, 2016, 79 (12) :E91-E96

[9]

Does anodal transcranial direct current stimulation enhance excitability of the motor cortex and motor function in healthy individuals and subjects with stroke: A systematic review and meta-analysis [J].

Bastani, A. ;

Jaberzadeh, S. .

CLINICAL NEUROPHYSIOLOGY, 2012, 123 (04) :644-657

[10]

Clinical utility of transcranial direct current stimulation (tDCS) for treating major depression: A systematic review and meta-analysis of randomized, double-blind and sham-controlled trials [J].

Berlim, Marcelo T. ;

Van den Eynde, Frederique ;

Daskalakis, Z. Jeff .

JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (01) :1-7

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