A case-control study to assess the risk of immune thrombocytopenia associated with vaccines

被引：59

作者：

Grimaldi-Bensouda, Lamiae ^{[1
,2
,3
]}

Michel, Marc

Aubrun, Elodie ^{[1
]}

Leighton, Pamela ^{[5
]}

Viallard, Jean-Francois ^{[6
]}

Adoue, Daniel ^{[7
]}

Magy-Bertrand, Nadine ^{[8
]}

Tisserand, Guillaume ^{[8
]}

Khellaf, Mehdi ^{[4
,9
]}

Durand, Jean-Marc ^{[9
]}

Quittet, Philippe ^{[10
]}

Fain, Olivier ^{[11
]}

Bonnotte, Bernard ^{[12
]}

Morin, Anne Sophie ^{[11
]}

Limal, Nicolas ^{[4
]}

Costedoat-Chalumeau, Nathalie ^{[13
]}

Morel, Nathalie ^{[13
]}

Pan-Petesch, Brigitte ^{[14
]}

Decaux, Olivier ^{[15
]}

Mahevas, Matthieu ^{[4
]}

Ruel, Michel ^{[16
]}

Sacre, Karim ^{[17
]}

Lefrere, Francois ^{[18
]}

Abenhaim, Lucien ^{[5
,19
]}

Godeau, Bertrand ^{[4
]}

机构：

[1] LA SER, F-75014 Paris, France

[2] Conservatoire Natl Arts & Metiers, Paris, France

[3] Inst Pasteur, INSERM, F-75724 Paris, France

[4] Univ Paris Est Creteil, Henri Mondor Univ Hosp, AP HP, Dept Internal Med,Natl Referral Ctr Adults Immune, Creteil, France

[5] LA SER Europe, London, England

[6] Univ Bordeaux, Hosp Haut Leveque, Bordeaux, France

[7] Univ Hosp Purpan, Toulouse, France

[8] Univ Hosp Jean Minjoz, Besancon, France

[9] Univ Hosp Concept, Marseille, France

[10] Univ Hosp St Eloi, Montpellier, France

[11] Univ Hosp Jean Verdier, Bondy, France

[12] Univ Hosp Le Bocage, Dijon, France

[13] Univ Hosp La Pitie Salpetriere, Paris, France

[14] Univ Hosp Morvan, Brest, France

[15] Univ Hosp Hop Sud, Rennes, France

[16] Hosp Max Fourestier, Nanterre, France

[17] Univ Hosp Bichat, Paris, France

[18] Univ Hosp Necker, Paris, France

[19] London Sch Hyg & Trop Med, London WC1, England

来源：

BLOOD | 2012年 / 120卷 / 25期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; INFLUENZA VACCINATION; MMR VACCINE; PURPURA; CHILDREN; CRITERIA; SAFETY; ADULTS; DRUG; CLASSIFICATION;

D O I：

10.1182/blood-2012-05-431098

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cause of immune thrombocytopenia (ITP) remains unknown. Studies have suggested immunizations as possible triggering factors of ITP through molecular mimicry. This case-control study explored potential associations between adult ITP and various routinely administered vaccines. A network of internal medicine and hematology centers across France recruited 198 incident (ie, newly diagnosed) cases of ITP between April 2008 and June 2011. These cases were compared with 878 age-and sex-matched controls without ITP recruited in general practice. Information on vaccination was obtained from patients' standardized telephone interviews. Sixty-six of 198 cases (33.3%) and 303 of 878 controls (34.5%) received at least 1 vaccine within the 12 months before the index date. We found no evidence of an increase in ITP after vaccination in the previous 6 or 12 months (adjusted odds ratio [OR] for the previous 12 months = 1.0; 95% confidence interval, 0.7-1.4). When the 2-month time window was used, higher ORs were observed for all vaccines (OR = 1.3). This increase was mainly attributable to the vaccination against diphtheria-tetanus-pertussis-poliomyelitis (OR = 1.5) and was not statistically significant. The results of the present study show that in an adult population, the exposure to common vaccines is on average not associated with an observable risk of developing ITP. (Blood. 2012; 120(25): 4938-4944)

引用

页码：4938 / 4944

页数：7

共 37 条

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