Impact of 5-Year Weight Change on Blood Pressure: Results From the Weight Loss Maintenance Trial

被引：48

作者：

Tyson, Crystal C. ^{[1
,2
,3
]}

Appel, Lawrence J. ^{[4
]}

Vollmer, William M. ^{[5
]}

Jerome, Gerald J. ^{[6
]}

Brantley, Phillip J. ^{[7
]}

Hollis, Jack F. ^{[5
]}

Stevens, Victor J. ^{[5
]}

Ard, Jamy D. ^{[8
]}

Patel, Uptal D. ^{[1
]}

Svetkey, Laura P. ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Nephrol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Duke Hypertens Ctr, Durham, NC USA

[3] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC USA

[4] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA

[5] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA

[6] Towson Univ, Dept Kinesiol, Towson, MD USA

[7] Pennington Biomed Res Ctr, Baton Rouge, LA USA

[8] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2013年 / 15卷 / 07期

关键词：

CARDIOVASCULAR RISK-FACTORS; REDUCTION; OBESE; INTERVENTION; PREVENTION; PHASE; AGE;

D O I：

10.1111/jch.12108

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

In this secondary analysis of the Weight Loss Maintenance trial, the authors assessed the relationship between blood pressure (BP) change and weight change in overweight and obese adults with hypertension and/or dyslipidemia who were randomized to 1 of 3 weight loss maintenance strategies for 5years. The participants were grouped (N=741) based on weight change from randomization to 60months as: (1) weight loss, (2) weight stable, or (3) weight gain. A significant positive correlation between weight change and systolic BP (SBP) change at 12, 30, and 60 months and between weight change and diastolic BP (DBP) change at 30months was observed. From randomization to 60months, mean SBP increased to a similar degree for the weight gain group (4.2 +/- standard error=0.6mmHg; P<.001) and weight stable group (4.6 +/- 1.1mmHg; P<.001), but SBP did not rise in the weight loss group (1.0 +/- 1.7mmHg, P=.53). DBP was unchanged for all groups at 60months. Although aging may have contributed to rise in BP at 60months, it does not appear to fully account for observed BP changes. These results suggest that continued modest weight loss may be sufficient for long-term BP lowering.

引用

页码：458 / 464

页数：7

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