A Metallo Pro-Drug to Target CuII in the Context of Alzheimer's Disease

被引：17

作者：

Conte-Daban, Amandine ^{[1
,2
]}

Ambike, Vinita ^{[4
]}

Guillot, Regis ^{[4
]}

Delsuc, Nicolas ^{[3
]}

Policar, Clotilde ^{[3
]}

Hureau, Christelle ^{[1
,2
]}

机构：

[1] CNRS, LCC, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France

[2] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France

[3] PSL Univ, Sorbonne Univ, CNRS, LBM,Dept Chim,Ecole Normale Super,Lab Biomol, F-75005 Paris, France

[4] Univ Paris Saclay, Univ Paris Sud 11, UMR CNRS 8182, Inst Chim Mol & Mat Orsay, Batiments 420,Rue Doyen Georges Poitou, F-91405 Orsay, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 20期

关键词：

Alzheimers disease; antioxidants; drug development; enzyme mimics; metal complexes; pro-drugs; AMYLOID-BETA PEPTIDE; MANGANESE SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; CU(II) AFFINITY; SMALL MOLECULES; COPPER; COORDINATION; AGGREGATION; IONS; COMPLEXES;

D O I：

10.1002/chem.201706049

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn-II-based superoxide dismutase (SOD) mimic ([Mn-II(L)](+), (1) under bar (+)) as a pro-drug candidate to target Cu-II-associated events, namely, Cu-II-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (A beta) peptide aggregation. Complex (1) under bar (+) is able to remove Cu-II from A beta, stop ROS and prevent alteration of A beta aggregation as would do the corresponding free ligand LH. Using (1) under bar (+) instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity.

引用

页码：5095 / 5099

页数：5

共 50 条

[1]

Cu(II) Affinity for the Alzheimer's Peptide: Tyrosine Fluorescence Studies Revisited [J].

Alies, Bruno ;

Renaglia, Emelyne ;

Rozga, Malgorzata ;

Bal, Wojciech ;

Faller, Peter ;

Hureau, Christelle .

ANALYTICAL CHEMISTRY, 2013, 85 (03) :1501-1508

[2]

Atrian-Blasco E., UNPUB

[3]

Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level [J].

Atrian-Blasco, Elena ;

Conte-Daban, Amandine ;

Hureau, Christelle .

DALTON TRANSACTIONS, 2017, 46 (38) :12750-12759

[4]

Batinic-Haberle I, 2016, OXID STRESS APPL BAS, P165, DOI 10.1007/978-3-319-30705-3_8

[5]

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways [J].

Batinic-Haberle, Ines ;

Tovmasyan, Artak ;

Roberts, Emily R. H. ;

Vujaskovic, Zeljko ;

Leong, Kam W. ;

Spasojevic, Ivan .

ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (15) :2372-2415

[6]

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential [J].

Batinic-Haberle, Ines ;

Reboucas, Julio S. ;

Spasojevic, Ivan .

ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (06) :877-918

[7]

Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages [J].

Bernard, Anne-Sophie ;

Giroud, Claire ;

Ching, H. Y. Vincent ;

Meunier, Anne ;

Ambike, Vinita ;

Amatore, Christian ;

Collignon, Manon Guille ;

Lemaitre, Frederic ;

Policar, Clotilde .

DALTON TRANSACTIONS, 2012, 41 (21) :6399-6403

[8]

Cassagnes L.-E., 2013, ANGEW CHEM, V125, P11316

[9]

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production [J].

Cassagnes, Laure-Estelle ;

Herve, Vincent ;

Nepveu, Francoise ;

Hureau, Christelle ;

Faller, Peter ;

Collin, Fabrice .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (42) :11110-11113

[10]

Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds [J].

Chassaing, Stefan ;

Collin, Fabrice ;

Dorlet, Pierre ;

Gout, Jerome ;

Hureau, Christelle ;

Faller, Peter .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (22) :2573-2595

← 1 2 3 4 5 →