Mucosal delivery of vaccines

被引：14

作者：

Del Giudice, G ^{[1
]}

Pizza, M ^{[1
]}

Rappuoli, R ^{[1
]}

机构：

[1] Chiron SPA, IRIS Res Ctr, I-553100 Siena, Italy

来源：

METHODS | 1999年 / 19卷 / 01期

关键词：

D O I：

10.1006/meth.1999.0840

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Oral delivery represents one of the most pursued approaches for large-scale human vaccination. Due to the different characteristics of mucosal immune response, as compared with systemic response, oral immunization requires particular methods of antigen preparation and selective strategies of adjuvanticity. In this paper, we describe the preparation and use of genetically detoxified bacterial toxins as mucosal adjuvants and envisage the possibility of their future exploitation for human oral vaccines. (C) 1999 Academic Press.

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收藏

页码：148 / 155

页数：8

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