Human eosinophils lack human leukocyte elastase

被引：19

作者：

Wiedow, O

Muhle, K

Streit, V

Kameyoshi, Y

机构：

[1] Department of Dermatology, University of Kiel, D-24105 Kiel

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1315卷 / 03期

关键词：

human leukocyte elastase; eosinophil;

D O I：

10.1016/0925-4439(95)00121-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, human leukocyte elastase has been detected in human eosinophils. Reinvestigating these findings, 2.5 pg active human leukocyte elastase (E.C. 3.4.21.37) were found per neutrophil isolated from peripheral blood, whereas the elastase activity of eosinophil preparations was linearly correlated with the content of contaminating neutrophils. Also spontaneous or stimulated release of active elastase was absent in eosinophils. By immunohistochemistry no elastase immunoreactivity could be demonstrated in human eosinophils. Therefore, we conclude that human eosinophils do not contain considerable amounts of human leukocyte elastase.

引用

页码：185 / 187

页数：3

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