Minimal functional model of hemostasis in a biomimetic microfluidic system

被引：49

作者：

Runyon, MK ^{[1
]}

Johnson-Kerner, BL ^{[1
]}

Ismagilov, RF ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

autocatalysis; biomimetic synthesis; hemostasis; microfluidic systems; self-repairing systems;

D O I：

10.1002/anie.200353428

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.

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页码：1531 / 1536

页数：6

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