Engineering myocardial tissue

被引:191
作者
Eschenhagen, T [1 ]
Zimmermann, WH [1 ]
机构
[1] Univ Hamburg Eppendorf, Med Ctr, Inst Expt & Clin Pharmacol, Hamburg, Germany
关键词
tissue engineering; heart; stem cells; regeneration;
D O I
10.1161/01.RES.0000196562.73231.7d
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To create an artificial heart is one of the most ambitious dreams of the young field of tissue engineering, a dream that, when publicly announced in 1999 ( LIFE initiative around M. Sefton), provoked as much compassion as scepticism in the scientific and lay press. Today, it is fair to state that the field is still far away from having built the "bioartificial heart." Nevertheless, substantial progress has been made over the past 10 years, and a realistic perspective exists to create 3-dimensional heart muscle equivalents that may not only serve as experimental models but could also be useful for cardiac regeneration.
引用
收藏
页码:1220 / 1231
页数:12
相关论文
共 113 条
[1]   Cardiac organogenesis in vitro:: Reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cells [J].
Akins, RE ;
Boyce, RA ;
Madonna, ML ;
Schroedl, NA ;
Gonda, SR ;
McLaughlin, TA ;
Hartzell, CR .
TISSUE ENGINEERING, 1999, 5 (02) :103-118
[2]   POSTNATAL-DEVELOPMENT OF THE M-BAND IN RAT CARDIAC MYOFIBRILS [J].
ANVERSA, P ;
OLIVETTI, G ;
BRACCHI, PG ;
LOUD, AV .
CIRCULATION RESEARCH, 1981, 48 (04) :561-568
[3]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[4]   Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [J].
Badorff, C ;
Brandes, RP ;
Popp, R ;
Rupp, S ;
Urbich, C ;
Aicher, A ;
Fleming, I ;
Busse, R ;
Zeiher, A ;
Dimmeler, S .
CIRCULATION, 2003, 107 (07) :1024-1032
[5]   Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium [J].
Balsam, LB ;
Wagers, AJ ;
Christensen, JL ;
Kofidis, T ;
Weissman, IL ;
Robbins, RC .
NATURE, 2004, 428 (6983) :668-673
[6]   Adult cardiac stem cells are multipotent and support myocardial regeneration [J].
Beltrami, AP ;
Barlucchi, L ;
Torella, D ;
Baker, M ;
Limana, F ;
Chimenti, S ;
Kasahara, H ;
Rota, M ;
Musso, E ;
Urbanek, K ;
Leri, A ;
Kajstura, J ;
Nadal-Ginard, B ;
Anversa, P .
CELL, 2003, 114 (06) :763-776
[7]   STRUCTURAL BASIS OF END-STAGE FAILURE IN ISCHEMIC CARDIOMYOPATHY IN HUMANS [J].
BELTRAMI, CA ;
FINATO, N ;
ROCCO, M ;
FERUGLIO, GA ;
PURICELLI, C ;
CIGOLA, E ;
QUAINI, F ;
SONNENBLICK, EH ;
OLIVETTI, G ;
ANVERSA, P .
CIRCULATION, 1994, 89 (01) :151-163
[8]   MORPHOLOGICAL DEVELOPMENT OF THE RAT-HEART GROWING INOCULO IN THE ABSENCE OF HEMODYNAMIC WORK LOAD [J].
BISHOP, SP ;
ANDERSON, PG ;
TUCKER, DC .
CIRCULATION RESEARCH, 1990, 66 (01) :84-102
[9]   Electrospinning collagen and elastin: Preliminary vascular tissue engineering [J].
Boland, ED ;
Matthews, JA ;
Pawlowski, KJ ;
Simpson, DG ;
Wnek, GE ;
Bowlin, GL .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 :1422-1432
[10]   Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity [J].
Brutsaert, DL .
PHYSIOLOGICAL REVIEWS, 2003, 83 (01) :59-115