Treatment of recalcitrant atopic dermatitis with omalizumab

被引:141
作者
Lane, JE [1 ]
Cheyney, JM
Lane, TN
Kent, DE
Cohen, DJ
机构
[1] Mercer Univ, Sch Med, Dept Internal Med, Div Dermatol, Macon, GA 31217 USA
[2] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA
关键词
D O I
10.1016/j.jaad.2005.09.030
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Atopic dermatitis is a common diagnosis that presents a therapeutic challenge. Although multiple therapeutic modalities exist, there is no single monotherapy that has proven exceptional in ameliorating the symptoms of this disease. Current topical and systemic therapeutic options offer benefit but carry varying degrees of adverse effects that often limit their application. We present 3 patients with severe, recalcitrant atopic dermatitis successfully treated with omalizumab.
引用
收藏
页码:68 / 72
页数:5
相关论文
共 19 条
[11]  
Maurer D, 1996, J IMMUNOL, V157, P607
[12]   Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients [J].
Natter, S ;
Seiberler, S ;
Hufnagl, P ;
Binder, BR ;
Hirschl, AM ;
Ring, J ;
Abeck, D ;
Schmidt, T ;
Valent, P ;
Valenta, R .
FASEB JOURNAL, 1998, 12 (14) :1559-1569
[13]  
Nayak A, 2003, ALLERGY ASTHMA PROC, V24, P323
[14]   Targeting immunoglobulin E as a novel treatment for asthma [J].
Sandström, T .
CURRENT ALLERGY AND ASTHMA REPORTS, 2005, 5 (02) :109-115
[15]   INHIBITION OF ALLERGIC REACTIONS WITH ANTIBODIES TO IGE [J].
SHIELDS, RL ;
WHETHER, WR ;
ZIONCHECK, K ;
OCONNELL, L ;
FENDLY, B ;
PRESTA, LG ;
THOMAS, D ;
SABAN, R ;
JARDIEU, P .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (1-3) :308-312
[16]   IgE-mediated, FcεRI-dependent allergen presentation:: A pathogenetic factor in atopic dermatitis? [J].
Stingl, G .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (01) :S17-S20
[17]  
*US FDA, 2003, BRIEF DOC SAF OM XOL
[18]   Immunoglobulin E response to human proteins in atopic patients [J].
Valenta, R ;
Maurer, D ;
Steiner, R ;
Seiberler, S ;
Sperr, WR ;
Valent, P ;
Spitzauer, S ;
Kapiotis, S ;
Smolen, J ;
Stingl, G .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 107 (02) :203-208
[19]  
Valenta R, 1999, CURR PROBL DERMATOL, V28, P45