Tracing hepatitis B virus to the 16th century in a Korean mummy

被引:91
作者
Bar-Gal, Gila Kahila [3 ]
Kim, Myeung Ju [4 ]
Klein, Athalia [1 ]
Shin, Dong Hoon [2 ]
Oh, Chang Seok [2 ]
Kim, Jong Wan [5 ]
Kim, Tae-Hyun [6 ]
Kim, Seok Bae [7 ]
Grant, Paul R. [8 ]
Pappo, Orit [9 ]
Spigelman, Mark [10 ,11 ]
Shouval, Daniel [1 ]
机构
[1] Hadassah Hebrew Univ Hosp, Liver Unit, IL-91120 Jerusalem, Israel
[2] Seoul Natl Univ, Dept Anat, Coll Med, Anthropol & Paleopathol Lab,Inst Forens Med, Seoul 110799, South Korea
[3] Hebrew Univ Jerusalem, Koret Sch Vet Med, IL-76100 Rehovot, Israel
[4] Dankook Univ, Dept Anat, Coll Med, Cheonan, South Korea
[5] Dankook Univ, Dept Lab Med, Coll Med, Cheonan, South Korea
[6] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan, South Korea
[7] Dankook Univ, Dept Internal Med, Coll Med, Cheonan, South Korea
[8] UCL, Dept Virol, NHS Trust, London, England
[9] Hadassah Hebrew Univ Hosp, Dept Pathol, IL-91120 Jerusalem, Israel
[10] UCL, Ctr Clin Microbiol, London, England
[11] Hebrew Univ Jerusalem, Dept Parasitol, Kuvin Ctr, Jerusalem, Israel
关键词
GENOTYPE-C; CLINICAL CHARACTERISTICS; GEOGRAPHIC-DISTRIBUTION; GENETIC-VARIABILITY; CHILD MUMMY; DNA; INFECTION; SUBGENOTYPES; DIVERSITY; YANGJU;
D O I
10.1002/hep.25852
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
A rare find of a mummified child from the 16th century AD, in Korea, with relatively preserved organs, enabled a search for ancient hepatitis B virus (aHBV) DNA sequences from laparoscopic-derived liver biopsies. Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype C2 (HBV/C2) sequence commonly spread in Southeast Asia, which probably represents an HBV that infected the Joseon Dynasty population in Korea. Comparison of the aHBV sequences with contemporary HBV/C2 DNA sequences revealed distinctive differences along four open reading frames. Genetic diversity between contemporary and recovered aHBV/C2 DNA may be the result of immunologic, environmental, and/or pharmacologic pressures. The calculated time of most recent common ancestor suggests that the Korean HBV sequence origin dates back at least 3,000 years and possibly as long as 100,000 years. This isolate most likely represents the earliest human HBV sequence that colonized Southeast Asia by human migration. Conclusion: This study describes the complete sequence of the oldest HBV isolate and the most ancient full viral genome known so far. (HEPATOLOGY 2012;56:16711680)
引用
收藏
页码:1671 / 1680
页数:10
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