Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]-naphthyridines as novel topoisomerase I-targeting antitumor agents

被引：16

作者：

Feng, Wei ^{[1
]}

Satyanarayana, Mavurapu ^{[1
]}

Cheng, Liang ^{[1
]}

Liu, Angela ^{[2
]}

Tsai, Yuan-Chin ^{[2
]}

Liu, Leroy F. ^{[2
,3
]}

LaVoie, Edmond J. ^{[1
,3
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

[3] Inst Canc Res, New Brunswick, NJ 08901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 20期

关键词：

topoisomerase I; cytotoxicity; antitumor; MDA-MB-435; structure-activity; non-camptothecin;

D O I：

10.1016/j.bmc.2008.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Several N-alkyl and N, N-dialkyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6] naphthyridin-6-ones have been identified as topoisomerase I-targeting agents with potent antitumor activity. In the present study, the impact on biological activity of substitution of a trifluoromethyl, cyano, aminocarbonyl, or ethynyl group on a N-methyl substituent of N, N-dimethyl-, N-methyl-N-ethyl-, and N-methyl-N-isopropyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6]naphthyridin- 6-ones was assessed. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9295 / 9301

页数：7

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