Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]-naphthyridines as novel topoisomerase I-targeting antitumor agents

被引:16
作者
Feng, Wei [1 ]
Satyanarayana, Mavurapu [1 ]
Cheng, Liang [1 ]
Liu, Angela [2 ]
Tsai, Yuan-Chin [2 ]
Liu, Leroy F. [2 ,3 ]
LaVoie, Edmond J. [1 ,3 ]
机构
[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA
[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
[3] Inst Canc Res, New Brunswick, NJ 08901 USA
关键词
topoisomerase I; cytotoxicity; antitumor; MDA-MB-435; structure-activity; non-camptothecin;
D O I
10.1016/j.bmc.2008.09.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Several N-alkyl and N, N-dialkyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6] naphthyridin-6-ones have been identified as topoisomerase I-targeting agents with potent antitumor activity. In the present study, the impact on biological activity of substitution of a trifluoromethyl, cyano, aminocarbonyl, or ethynyl group on a N-methyl substituent of N, N-dimethyl-, N-methyl-N-ethyl-, and N-methyl-N-isopropyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6]naphthyridin- 6-ones was assessed. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9295 / 9301
页数:7
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