Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping

被引：21

作者：

Donovan, JA

Simmons, FA

Esrason, KT

Jamehdor, M

Busuttil, RW

Novak, JM

Grody, WW

机构：

[1] SO CALIF PERMANENTE MED GRP,KAISER LOS ANGELES MED CTR,DEPT MED GENET,LOS ANGELES,CA 90027

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT SURG,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,SCH MED,DEPT LAB MED,LOS ANGELES,CA 90024

[5] UNIV CALIF LOS ANGELES,SCH MED,DEPT PEDIAT,LOS ANGELES,CA 90024

[6] SO CALIF PERMANENTE MED GRP,KAISER LOS ANGELES MED CTR,DEPT GASTROENTEROL,LOS ANGELES,CA 90027

来源：

TRANSPLANTATION | 1997年 / 63卷 / 01期

关键词：

D O I：

10.1097/00007890-199701150-00015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.

引用

页码：80 / 84

页数：5

共 19 条

[1]

DETECTION OF ENGRAFTMENT AND CHIMERISM AFTER BONE-MARROW TRANSPLANTATION BY INSITU HYBRIDIZATION USING A Y-CHROMOSOME SPECIFIC PROBE [J].