TPT1/ TCTP-regulated pathways in phenotypic reprogramming

被引：111

作者：

Amson, Robert ^{[1
]}

Pece, Salvatore ^{[2
,3
,4
]}

Marine, Jean-Christophe ^{[5
,6
]}

Di Fiore, Pier Paolo ^{[2
,3
,4
]}

Telerman, Adam ^{[1
]}

机构：

[1] Ecole Normale Super, LBPA, CNRS, UMR 8113, F-94235 Cachan, France

[2] Ist FIRC Oncol Mol, I-20139 Milan, Italy

[3] Ist Europeo Oncol, I-20141 Milan, Italy

[4] Univ Milan, Dipartimento Med Chirurg & Odontoiatria, I-20122 Milan, Italy

[5] VIB, Ctr Biol Dis, Lab Mol Canc Biol, B-3000 Louvain, Belgium

[6] Katholieke Univ Leuven, Lab Mol Canc Biol, B-3000 Louvain, Belgium

来源：

TRENDS IN CELL BIOLOGY | 2013年 / 23卷 / 01期

关键词：

p53; MDM2; tumor reversion; stem cells; CONTROLLED TUMOR PROTEIN; HISTAMINE-RELEASING FACTOR; TRANSLATIONAL CONTROL; NUCLEOTIDE EXCHANGE; EXOSOME SECRETION; P53; GROWTH; MOUSE; IDENTIFICATION; APOPTOSIS;

D O I：

10.1016/j.tcb.2012.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is structurally similar to mRNA-helicases and MSS4. TPT1/TCTP has recently been identified as a prognostic factor in breast cancer and a critical regulator of the tumor suppressor p53 and of the cancer stem cell (SC) compartment. Emerging evidence indicates that TPT1/TCTP is key to phenotypic reprogramming, as shown in the process of tumor reversion and possibly in pluripotency. We provide here an overview of these diverse functions of TPT1/TCTP.

引用

页码：37 / 46

页数：10

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