α-Synuclein as a ferrireductase

被引：46

作者：

Brown, David R. ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

关键词：

iron; Parkinson's disease; synuclein; FAMILIAL PARKINSONS-DISEASE; BETA-SYNUCLEIN; LEWY BODY; IN-VIVO; SYSTEM; EXPRESSION; DOPAMINE; BINDING; PROTEIN; BRAIN;

D O I：

10.1042/BST20130130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Many proteins associated with neurodegenerative diseases have poorly defined or unknown functions. alpha-Synuclein is one such protein which is associated with a range of diseases including Parkinson's disease. Now accepted as a metal-binding protein, alpha-synuclein's function could possibly be defined in relation to the binding of cofactors. It has been suggested recently that alpha-synuclein is able to reduce iron using copper as its catalytic centre. The consequence of this is that possibly the function of alpha-synuclein can now be defined. The evidence for this and the consequences for Parkinson's disease are discussed in the present review.

引用

页码：1513 / 1517

页数：5

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