Effects of 17 alpha,20 beta-dihydroxy-4-pregnen-3-one on cortisol production by rainbow trout interrenal tissue in vitro

被引:23
作者
Barry, TP [1 ]
Riebe, JD [1 ]
Parrish, JJ [1 ]
Malison, JA [1 ]
机构
[1] DEPT ANIM SCI,MADISON,WI 53706
基金
美国海洋和大气管理局;
关键词
D O I
10.1006/gcen.1997.6910
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Physiological levels of 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (17,20-P) stimulated time- and dose-dependent increases in cortisol production by rainbow trout (Oncorhynchus mykiss) interrenal tissue cultured in vitro. Significant stimulation occurred in response to 100, 300, and 1000 ng/ml of 17,20-P. Lower doses were ineffective. Elevated cortisol levels were observed 1 hr after addition of 300 ng/ml 17,20-P. No additive or synergistic interaction was evident between human adrenocorticotropin fragment 1-24 (ACTH(1-24)) and 17,20-P in stimulating cortisol secretion, although 300 ng/ml 17,20-P could further enhance cortisol production above levels already stimulated by 300 ng/ml ACTH. 17 alpha,20 alpha-dihydroxy-4-pregnen-3-one also stimulated cortisol secretion, but was only half as effective as 17,20-P. Estradiol-17 beta, testosterone, and 11-ketotestosterone had no effect on cortisol secretion. Inhibitors of mRNA and protein synthesis had no effect on 17,20-P-stimulated cortisol production. Radiotracer studies demonstrated that the bioconversion of 17,20-P to cortisol could fully account for the cortisol produced by the interrenal in response to 17,20-P and demonstrated that rainbow trout interrenal cells contain an active 20 beta-hydroxysteroid dehydrogenase. These data suggest that 17,20-P may be a regulator of cortisol production during the periovulatory period in salmonid fishes. (C) 1997 Academic Press.
引用
收藏
页码:172 / 181
页数:10
相关论文
共 37 条
[1]   INCREASED SUBSTRATE CONCENTRATION CAUSES A SHIFT FROM PRODUCTION OF 11-OXYGENATED ANDROGENS TO 17,20-DIHYDROXYPROGESTOGENS DURING THE IN-VITRO METABOLISM OF 17-HYDROXYPROGESTERONE BY GOLDFISH TESTES [J].
ABDULLAH, MAS ;
KIME, DE .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1994, 96 (01) :129-139
[2]   IN VITRO TRANSFORMATION OF STEROIDS BY HEAD KIDNEY BODY KIDNEY AND CORPUSCLES OF STANNIUS OF RAINBOW TROUT (SALMO GAIRDNERI) [J].
ARAI, R ;
TAJIMA, H ;
TAMAOKI, BI .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1969, 12 (01) :99-+
[3]   BIOSYNTHESIS OF 17-ALPHA,20-ALPHA-DIHYDROXY-4-PREGNEN-3-ONE FROM 17-ALPHA-HYDROXYPROGESTERONE BY SPERMATOZOA OF THE COMMON CARP, CYPRINUS-CARPIO [J].
ASAHINA, K ;
BARRY, TP ;
AIDA, K ;
FUSETANI, N ;
HANYU, I .
JOURNAL OF EXPERIMENTAL ZOOLOGY, 1990, 255 (02) :244-249
[4]   EFFECTS OF 17-ALPHA,20-BETA-DIHYDROXY-4-PREGNEN-3-ONE ON THE INVITRO PRODUCTION OF 11-KETOTESTOSTERONE BY TESTICULAR FRAGMENTS OF THE COMMON CARP, CYPRINUS-CARPIO [J].
BARRY, TP ;
AIDA, K ;
HANYU, I .
JOURNAL OF EXPERIMENTAL ZOOLOGY, 1989, 251 (01) :117-120
[5]   VALIDATION OF A MICROTITRE PLATE ELISA FOR MEASURING CORTISOL IN FISH AND COMPARISON OF STRESS RESPONSES OF RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) AND LAKE TROUT (SALVELINUS-NAMAYCUSH) [J].
BARRY, TP ;
LAPP, AF ;
KAYES, TB ;
MALISON, JA .
AQUACULTURE, 1993, 117 (3-4) :351-363
[6]   THE SHIFT FROM C-19 TO C-21 STEROID-SYNTHESIS IN SPAWNING MALE COMMON CARP, CYPRINUS-CARPIO, IS REGULATED BY THE INHIBITION OF ANDROGEN PRODUCTION BY PROGESTOGENS PRODUCED BY SPERMATOZOA [J].
BARRY, TP ;
AIDA, K ;
OKUMURA, T ;
HANYU, I .
BIOLOGY OF REPRODUCTION, 1990, 43 (01) :105-112
[7]  
Billard R., 1981, P185
[9]   PRELIMINARY EVIDENCE THAT CHRONIC CONFINEMENT STRESS REDUCES THE QUALITY OF GAMETES PRODUCED BY BROWN AND RAINBOW-TROUT [J].
CAMPBELL, PM ;
POTTINGER, TG ;
SUMPTER, JP .
AQUACULTURE, 1994, 120 (1-2) :151-169
[10]   STRESS REDUCES THE QUALITY OF GAMETES PRODUCED BY RAINBOW-TROUT [J].
CAMPBELL, PM ;
POTTINGER, TG ;
SUMPTER, JP .
BIOLOGY OF REPRODUCTION, 1992, 47 (06) :1140-1150