Summarizing differences in cumulative incidence functions

被引:38
作者
Zhang, Mei-Jie [1 ]
Fine, Jason [2 ]
机构
[1] Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
[2] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA
关键词
competing risk; counting processes; marginal probability function; nonparametric measures; time-dependent summaries; two sample problem;
D O I
10.1002/sim.3339
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cumulative incidence function is widely reported in competing risks studies, with group differences assessed by an extension of the log-rank test. However, simple, interpretable summaries of group differences are not available. Ail adaptation of the proportional hazards model to the Cumulative incidence function is often employed, but the interpretation of the hazard ratio may be somewhat awkward, unlike the usual survival set-LIP. We propose nonparametric inferences for general summary measures, which may be time-varying, and for time-averaged versions of the measures. Theoretical justification is provided using counting process techniques. A real data example illustrates the practical utility of the methods. Copyright (C) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码:4939 / 4949
页数:11
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