Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

被引：418

作者：

Song, Jin-Wen ^{[1
]}

Lam, Sin Man ^{[2
,4
]}

Fan, Xing ^{[1
]}

Cao, Wen-Jing ^{[1
,3
]}

Wang, Si-Yu ^{[1
]}

Tian, He ^{[2
]}

Chua, Gek Huey ^{[4
]}

Zhang, Chao ^{[1
]}

Meng, Fan-Ping ^{[1
]}

Xu, Zhe ^{[1
]}

Fu, Jun-Liang ^{[1
]}

Huang, Lei ^{[1
]}

Xia, Peng ^{[1
]}

Yang, Tao ^{[1
]}

Zhang, Shaohua ^{[2
]}

Li, Bowen ^{[4
]}

Jiang, Tian-Jun ^{[1
]}

Wang, Raoxu ^{[2
]}

Wang, Zehua ^{[2
]}

Shi, Ming ^{[1
]}

Zhan, Ji-Yuan ^{[1
]}

Wang, Fu-Sheng ^{[1
]}

Shui, Guanghou ^{[2
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Med Ctr 5, Natl Clin Res Ctr Infect Dis, Treatment & Res Ctr Infect Dis, Beijing 100039, Peoples R China

[2] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China

[3] Bengbu Med Coll, Dept Clin Med, Bengbu 233000, Peoples R China

[4] LipidALL Technol Co Ltd, Changzhou 213022, Jiangsu, Peoples R China

来源：

CELL METABOLISM | 2020年 / 32卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CELL-DERIVED EXOSOMES; ALVEOLAR MACROPHAGES; LIPIDOMICS; CORONAVIRUS; PLASMA; BIOGENESIS; INCREASE; UNRAVELS; PLATFORM; INDUCE;

D O I：

10.1016/j.cmet.2020.06.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of metabolic dysregulation in COVID-19 was performed using multiscale embedded differential correlation network analyses. Using exosomes isolated from the same cohort, we demonstrated that exosomes of COVID-19 patients with elevating disease severity were increasingly enriched in GM3s. Our work suggests that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis and presents the largest repository on the plasma lipidome and metabolome distinct to COVID-19.

引用

页码：188 / +

页数：20

共 68 条

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