Development of phase-contrast X-ray imaging techniques and potential medical applications

被引:225
作者
Zhou, Shu-Ang [1 ]
Brahme, Anders [1 ]
机构
[1] Karolinska Inst, Dept Oncol Pathol, Div Med Radiat Phys, SE-17176 Stockholm, Sweden
来源
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2008年 / 24卷 / 03期
关键词
Phase-contrast; X-ray imaging; Soft tissue contrast; Phase-contrast stereography;
D O I
10.1016/j.ejmp.2008.05.006
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A significant improvement over conventional attenuation-based X-ray imaging, which tacks contrast in small objects and soft biological tissues, is obtained by introducing phase-contrast imaging. As recently demonstrated, phase-contrast imaging is characterized by its extraordinary image quality, greatly enhanced contrast, and good soft tissue discrimination with very high spatial resolution down to the micron and even the sub-micron region. The rapid development of compact X-ray sources of high brightness, tuneability, and monochromaticity as well as high-resolution X-ray detectors with high quantum efficiency and improved computational methods is stimulating the development of a new generation of X-ray imaging systems for medical applications. The present paper reviews some intrinsic mechanisms, recent technical developments and potential medical applications of two-, three- and four-dimensional phase-contrast X-ray imaging. Challenging issues in current phase-contrast imaging techniques and key clinical applications are discussed and possible developments of future high-contrast and high spatial and temporal resolution medical X-ray imaging systems are outlined. (C) 2008 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.
引用
收藏
页码:129 / 148
页数:20
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