The specific identification of cellular senescence in clinical material has important implications for determining the role of senescence in age-related pathologies and in neoplasia in certain tumours. One suggested marker of senescence is the histochernical identification of a specific beta-galactosidase enzyme operative at pH 6.0. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid beta-galactosidase, which is expressed by a variety of differentiated cell types. Copyright (C) 2002 John Wiley Sons, Ltd.
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Ding, GH
;
Franki, N
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Franki, N
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Kapasi, AA
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Kapasi, AA
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Reddy, K
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Reddy, K
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Gibbons, N
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Gibbons, N
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Singhal, PC
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Ding, GH
;
Franki, N
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Franki, N
;
Kapasi, AA
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Kapasi, AA
;
Reddy, K
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Reddy, K
;
Gibbons, N
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA
Gibbons, N
;
Singhal, PC
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Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USAAlbert Einstein Coll Med, Long Isl Jewish Med Ctr, Div Kidney Dis & Hypertens, Sect Mol Biol & Expt Pathol, New Hyde Park, NY 11040 USA