Markers of senescence?

被引：30

作者：

Coates, PJ ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

来源：

JOURNAL OF PATHOLOGY | 2002年 / 196卷 / 04期

关键词：

senescence; beta-galactosidase; telomerase;

D O I：

10.1002/path.1073

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The specific identification of cellular senescence in clinical material has important implications for determining the role of senescence in age-related pathologies and in neoplasia in certain tumours. One suggested marker of senescence is the histochernical identification of a specific beta-galactosidase enzyme operative at pH 6.0. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid beta-galactosidase, which is expressed by a variety of differentiated cell types. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：371 / 373

页数：3

共 20 条

[1] Telomerase activity: A biomarker of cell proliferation, not malignant transformation [J].

Belair, CD ;

Yeager, TR ;

Lopez, PM ;

Reznikoff, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13677-13682

[2] Cellular senescence as a tumor-suppressor mechanism [J].

Campisi, J .

TRENDS IN CELL BIOLOGY, 2001, 11 (11) :S27-S31

[3] A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO [J].

DIMRI, GP ;

LEE, XH ;

BASILE, G ;

ACOSTA, M ;

SCOTT, C ;

ROSKELLEY, C ;

MEDRANO, EE ;

LINSKENS, M ;

RUBELJ, I ;

PEREIRASMITH, O ;

PEACOCKE, M ;

CAMPISI, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9363-9367

[4] Tubular cell senescence and expression of TGF-β1 and p21WAF1/CIP1 in tubulointerstitial fibrosis of aging rats [J].

Ding, GH ;

Franki, N ;

Kapasi, AA ;

Reddy, K ;

Gibbons, N ;

Singhal, PC .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2001, 70 (01) :43-53

[5]

GOING JJ, 2002, J PATHOL

[6] LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS [J].

HAYFLICK, L .

EXPERIMENTAL CELL RESEARCH, 1965, 37 (03) :614-&

[7] LIPOFUSION ACCUMULATION RESULTING FROM SENESCENCE AND VITAMIN-E-DEFICIENCY - SPECTRAL PROPERTIES AND TISSUE DISTRIBUTION [J].

KATZ, ML ;

ROBISON, WG ;

HERRMANN, RK ;

GROOME, AB ;

BIERI, JG .

MECHANISMS OF AGEING AND DEVELOPMENT, 1984, 25 (1-2) :149-159

[8]

Keith WN, 2001, J PATHOL, V195, P404

[9] Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [J].

Kiyono, T ;

Foster, SA ;

Koop, JI ;

McDougall, JK ;

Galloway, DA ;

Klingelhutz, AJ .

NATURE, 1998, 396 (6706) :84-88

[10] Does pH 6 β-galactosidase activity indicate cell senescence? [J].

Krishna, DR ;

Sperker, B ;

Fritz, P ;

Klotz, U .

MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 109 (02) :113-123

← 1 2 →