Pregnancy complications in PCOS

被引：96

作者：

Homburg, Roy ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Reprod Med Div, NL-1007 MB Amsterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2006年 / 20卷 / 02期

关键词：

PCOS; early pregnancy loss; gestational diabetes; pregnancy-induced hypertension; small-for-gestational-age; metformin;

D O I：

10.1016/j.beem.2006.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Complications of pregnancy associated with maternal PCOS include increased prevalence of early pregnancy loss (EPL), gestational diabetes (GDM), pregnancy-induced hypertensive disorders (PET/PIH), and the birth of small-for-gestational-age (SGA) babies. Increased risk of EPL has been attributed to obesity, hyperinsulinaemia, elevated luteinizing hormone concentrations, and endometrial dysfunction. Avoiding obesity before pregnancy and treatment with metformin are therapeutic options, also for the increased prevalence of GDM. Administration of metformin throughout pregnancy is a contentious issue. Screening pregnant women with PCOS for GDM and PET/PlH specially if they are obese is recommended, although data for a firm association between PCOS and PET/PIH is weak. Impaired insulin-mediated growth and fetal programming are possible explanations for a higher prevalence of SGA infants in mothers with PCOS. Only prospective studies employing a large cohort of women with well-defined PCOS compared with a control group matched for BMI and parity can solve the remaining questions.

引用

页码：281 / 292

页数：12

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