The mechanisms of brain ischemic insult and potential protective interventions

被引：29

作者：

Guo, Zhao-Hui ^{[1
]}

Li, Feng ^{[1
]}

Wang, Wei-Zhi ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Neurol, Affiliated Hosp 2, Harbin 150086, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2009年 / 25卷 / 03期

基金：

中国博士后科学基金;

关键词：

brain ischemia; glutamate receptors; calcium toxicity; endoplasmic reticulum stress; neuroprotection;

D O I：

10.1007/s12264-009-0104-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanisms of brain ischemic insult include glutamate excitoxicity, calcium toxicity, free radicals, nitric oxide, inflammatory reactions, as well as dysfunctions of endoplasmic reticulum and mitochondrion. These injury cascades are interconnected in complex ways, thus it is hard to compare their pathogenic importances in ischemia models. And the research in cellular and molecular pathways has spurred the studies in potential neuroprotections mainly in pharmacological fields, such as anti-excitotoxic treatment, calcium-channel antagonism, approaches for inhibition of oxidation, inflammation and apoptosis, etc. Besides, other protective interventions including thrombolysis, arteriogenesis, regeneration therapy, and ischemia preconditioning or postconditioning, are also under investigations. Despite the present difficulties, we are quite optimistic towards future clinical applications of neuroprotective agents, by optimizing experimental approaches and clinical trials.

引用

页码：139 / 152

页数：14

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