Generation and function of human regulatory CD8+T cells induced by a humanized OKT3 monoclonal antibody hOKT3γ1(Ala-Ala)

被引：11

作者：

Ablamunits, Vitaly ^{[1
]}

Herold, Kevan C. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

HUMAN IMMUNOLOGY | 2008年 / 69卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Regulatory T cell; CD8; Anti-CD3; antibody;

D O I：

10.1016/j.humimm.2008.08.290

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies with a humanized anti-CD3 antibody in clinical trials suggested that this drug can induce regulatory CD8 + T cells. In this review, we discuss how these regulatory human CD8 + cells can be generated and the possible molecular tools they may use to inhibit immune responses. We compare our data on CD8 divided by regulatory cells induced by anti-CD3 stimulation with those reported in other experimental systems to identify both common and unique features of these cells. (c) 2008 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.

引用

页码：732 / 736

页数：5

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