How ageing processes influence cancer

被引：286

作者：

de Magalhaes, Joao Pedro ^{[1
]}

机构：

[1] Univ Liverpool, Integrat Genom Ageing Grp, Inst Integrat Biol, Liverpool L69 3BX, Merseyside, England

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

NAKED MOLE-RAT; DETECTABLE CLONAL MOSAICISM; FATAL NEOPLASTIC DISEASES; DNA-DAMAGE RESPONSE; EXTENDS LIFE-SPAN; FACTOR I LEVELS; CELLULAR SENESCENCE; CALORIC RESTRICTION; DIETARY RESTRICTION; GENOME REARRANGEMENTS;

D O I：

10.1038/nrc3497

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of the biology of ageing inform cancer biology?

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收藏

页码：357 / 365

页数：9

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