Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History

被引:382
作者
Brooks, Andrew W. [1 ,2 ]
Kohl, Kevin D. [1 ]
Brucker, Robert M. [1 ,3 ]
van Opstal, Edward J. [1 ]
Bordenstein, Seth R. [1 ,4 ]
机构
[1] Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Vanderbilt Genet Inst, 221 Kirkland Hall, Nashville, TN 37235 USA
[3] Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA
[4] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, 221 Kirkland Hall, Nashville, TN 37235 USA
基金
美国国家科学基金会;
关键词
GUT MICROBIOTA; INTESTINAL MICROBIOTA; PHYLOGENY; BACTERIA; DIET; PERFORMANCE; DIVERGENCE; HOMEOSTASIS; SPECIATION; DISTANCE;
D O I
10.1371/journal.pbio.2000225
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the prevalence of phylosymbiosis and its functional significance under highly controlled conditions by characterizing the microbiota of 24 animal species from four different groups (Peromyscus deer mice, Drosophila flies, mosquitoes, and Nasonia wasps), and we reevaluate the phylosymbiotic relationships of seven species of wild hominids. We demonstrate three key findings. First, intraspecific microbiota variation is consistently less than interspecific microbiota variation, and microbiota-based models predict host species origin with high accuracy across the dataset. Interestingly, the age of host clade divergence positively associates with the degree of microbial community distinguishability between species within the host clades, spanning recent host speciation events (similar to 1 million y ago) to more distantly related host genera (similar to 108 million y ago). Second, topological congruence analyses of each group's complete phylogeny and microbiota dendrogram reveal significant degrees of phylosymbiosis, irrespective of host clade age or taxonomy. Third, consistent with selection on host-microbiota interactions driving phylosymbiosis, there are survival and performance reductions when interspecific microbiota transplants are conducted between closely related and divergent host species pairs. Overall, these findings indicate that the composition and functional effects of an animal's microbial community can be closely allied with host evolution, even across wide-ranging timescales and diverse animal systems reared under controlled conditions.
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页数:29
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