Reductive Cyclizations of Nitroarenes to Hydroxamic Acids by Visible Light Photoredox Catalysis

被引：12

作者：

Cismesia, Megan A. ^{[1
]}

Ischay, Michael A. ^{[1
]}

Yoon, Tehshik P. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 19期

基金：

美国国家科学基金会;

关键词：

electron transfer; heterocycles; hydroxamic acids; photochemistry; reduction; PHOTOCATALYSIS; CYCLOADDITION; STRATEGY;

D O I：

10.1055/s-0033-1338419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically important N-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated.

引用

页码：2699 / 2705

页数：7

共 41 条

[1]

[Anonymous], J CHEM SOC REV

[2]

Claffey M. M., 2010, WIPO Patent, Patent No. [WO2010146488A1, 2010146488, WO 2010/146488]

[3]

COUTTS RT, 1963, J CHEM SOC, P4610

[4] SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME CHLORO ANALOGS OF 3-AMINO-3,4-DIHYDRO-1-HYDROXYCARBOSTYRIL [J].