Uncoupling protein 3 biological activity

被引：8

作者：

Giacobino, JP ^{[1
]}

机构：

[1] Ctr Med Univ Geneva, Dept Biochem Med, CH-1211 Geneva 4, Switzerland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷

关键词：

transgenic; glucose; fibre types;

D O I：

10.1042/BST0290774

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypothesis that uncoupling protein 3 (UCP3) is an uncoupling protein involved in heat dissipation is not unequivocally supported. An update of in vitro, ex vivo and in vivo studies testing this hypothesis is presented. Data are provided showing that exercise induces a fatty acid-dependent increase in muscle UCP3 mRNA in humans. The proposed positive correlation between glycolytic capacity and UCP3 level in various muscle-fibre types in the mouse is reassessed. Finally, an association between an intronic polymorphism of UCP3 and adiposity is reported.

引用

页码：774 / 777

页数：4

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