A novel dendritic cell subset involved in tumor immunosurveillance

被引：322

作者：

Taieb, J

Chaput, N

Ménard, C

Apetoh, L

Ullrich, E

Bonmort, M

Péquignot, M

Casares, N

Terme, M

Flament, C

Opolon, P

Lecluse, Y

Métivier, D

Tomasello, E

Vivier, E

Ghiringhelli, F

Martin, F

Klatzmann, D

Poynard, T

Tursz, T

Raposo, G

Yagita, H

Ryffel, B

Kroemer, G

Zitvogel, L ^{[1
]}

机构：

[1] Inst Gustave Roussy, Fac Med Kremlin Bicetre, INSERM, ERM0208, Villejuif, France

[2] Inst Gustave Roussy, CNRS, UMR8125, Villejuif, France

[3] Inst Gustave Roussy, IFR54, Flow Cytometry Core Facil, Villejuif, France

[4] Univ Mediterranee, Ctr Immunol Marseille Luminy, CNRS, INSERM, Marseille, France

[5] Fac Med, INSERM, U517, Dijon, France

[6] Grp Hosp Pitie Salpetriere, CERVI, UPMC, CNRS,UMR7087, F-75634 Paris, France

[7] Hop La Pitie Salpetriere, AH HP, Dept Gastroenterol, Paris, France

[8] Inst Curie, CNRS, UMR144, F-75231 Paris, France

[9] Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan

[10] Inst Transgenose, CNRS, IEM 2815, Orleans, France

来源：

NATURE MEDICINE | 2006年 / 12卷 / 02期

关键词：

D O I：

10.1038/nm1356

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interferon (IFN)-gamma-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice(1,2). Here we show that the main source of IFN-gamma is not the conventional NK cell but a subset of B220(+)Ly6C(-) dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220(+)NK1.1(+) dendritic cells secrete high levels of IFN-gamma and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.

引用

页码：214 / 219

页数：6

共 26 条

[1] Identification of tumor-infiltrating macrophages as the killers of tumor cells after immunization in a rat model system [J].