Reduced blood bcl-2 protein concentration in patients on hemodialysis

被引：5

作者：

Buemi, M ^{[1
]}

Allegra, A ^{[1
]}

Corica, F ^{[1
]}

Ruello, M ^{[1
]}

Di Pasquale, G ^{[1
]}

Aloisi, C ^{[1
]}

Giaccobe, MS ^{[1
]}

Romeo, A ^{[1
]}

Frisina, N ^{[1
]}

机构：

[1] Policlin Univ, Dipartimento Med Interna, Cattedra Nefrol 2, Messina, Italy

来源：

BLOOD PURIFICATION | 1998年 / 16卷 / 06期

关键词：

apoptosis; bcl-2; protein; chronic renal failure; hemodialysis; lipoperoxidation; oxidative stress;

D O I：

10.1159/000014350

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The concentrations of bcl-2 protein that can block programmed cellular death in various cell lines were evaluated in blood samples from 10 uremic patients on hemodialysis, 10 uremics not yet on hemodialysis, and in 10 healthy controls. The bcl-2 protein variations tin uremics on dialysis) were ascertained in patients during the dialysis session. Oxidative stress was evaluated in all groups by assaying the products of intraerythrocytic lipoperoxidation. Dialyzed and nondialyzed uremic patients had higher bcl-2 protein concentrations than healthy subjects. Dialysis causes a significant reduction in the concentrations of bcl-2 protein which becomes statistically significant during the 3rd hour. In both groups of uremic patients a positive correlation was found between bcl-2 protein and products of lipoperoxidation.

引用

页码：312 / 316

页数：5

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