In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues

被引：7

作者：

Feldman, KS ^{[1
]}

Wilson, SL

Lawlor, MD

Lang, CH

Scheuchenzuber, WJ

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

[2] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

[3] Penn State Univ, Life Sci Consortium, University Pk, PA 16802 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0968-0896(01)00251-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Designed dimeric gallotannin analogues featuring two tetragalloylglucopyranose cores connected by various hydrocarbon linkers inhibit tumor necrosis factor-alpha secretion from lipopolysaccharide-stimulated human peripheral blood mononuclear cells by up to 53% (5-24 muM concentration range) compared to control. Comparable suppression of tumor necrosis factor-alpha levels (similar to 50% vs control) was observed in the plasma of rats co-treated with lipopolysaccharide and specific tannin analogues selected for their lack of interleukin 1-beta stimulating activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：47 / 55

页数：9

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