Functional implications of myocardial scar structure

被引:75
作者
Holmes, JW
Nunez, JA
Covell, JW
机构
[1] UNIV CALIF SAN DIEGO, SCH MED, DEPT BIOENGN, LA JOLLA, CA 92093 USA
[2] UNIV CALIF SAN DIEGO, SCH MED, DEPT MED, LA JOLLA, CA 92093 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 05期
关键词
collagen fiber orientation; infarct biomechanics; infarct healing; myocardial infarction; structure-function relationships; CANINE LEFT-VENTRICLE; MECHANICAL DISADVANTAGE; POLARIZED-LIGHT; INFARCTION; DEFORMATION; DOG; STIFFNESS; MICROSCOPY; EVOLUTION; ANEURYSMS;
D O I
10.1152/ajpheart.1997.272.5.H2123
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
During healing after myocardial infarction, scar collagen content and stiffness do not correlate. We studied regional mechanics and both area fraction and orientation of large collagen fibers 3 wk after coronary ligation in the pig. During passive inflation of isolated, arrested hearts, the scar tissue demonstrated significantly less circumferential strain but similar longitudinal and radial deformation in comparison with noninfarcted regions of the same hearts. The observed selective resistance to circumferential deformation was consistent with the finding that most of the large collagen fibers in the scar were oriented within 30 degrees of the local circumferential axis. Furthermore, data from a previous study indicate that during ventricular systole these scars resist circumferential stretching, whereas they deform similarly to noninfarcted myocardium in the longitudinal and radial directions. We conclude that large collagen fiber structure is an important determinant of scar mechanical properties and that scar anisotropy allows the scar to resist circumferential stretching while deforming compatibly with adjacent noninfarcted myocardium in the longitudinal and radial directions.
引用
收藏
页码:H2123 / H2130
页数:8
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