μ-Opioid receptor mRNA expression in proopiomelanocortin neurons of the rat arcuate nucleus

被引：21

作者：

Bouret, S

Prevot, V

Croix, D

Jégou, S

Vaudry, H

Stefano, GB

Beauvillain, JC

Mitchell, V

机构：

[1] INSERM, U422, IFR 22, F-590045 Lille, France

[2] INSERM, U413, IFRMP 23, F-76821 Mt St Aignan, France

[3] Beth Isreal Deaconess Med Ctr, Mind Body Med Inst, Boston, MA 02215 USA

[4] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 70卷 / 01期

关键词：

proopiomelanocortin; enkephalin; beta-endorphin; mu-opioid receptor; arcuate nucleus; reproduction;

D O I：

10.1016/S0169-328X(99)00132-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been previously demonstrated that the activity of proopiomelanocortin (POMC)-containing neurons in the rat arcuate nucleus is regulated by opiates, but the expression of opioid receptors in POMC neurons las never been reported. In the present study, we have applied a double-labeling in situ hybridization technique to investigate the occurrence of mu-opioid receptor mRNA on POMC neurons. We have found that 20 +/- 3% of arcuate POMC neurons express mu-opioid receptor mRNA and that the proportion of POMC neurons expressing mu-opioid receptor is higher in the caudal than in the rostral portion of the arcuate nucleus. Our data suggest that POMC neurons might be both auto-regulated by P-endorphin, and regulated by enkephalins. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：155 / 158

页数：4

共 26 条

[1] ENDOGENOUS CODEINE AND MORPHINE ARE STORED IN SPECIFIC BRAIN NEURONS [J].