Study of Chemical Ligation Via 17-, 18- and 19-Membered Cyclic Transition States

被引：20

作者：

Panda, Siva S. ^{[1
]}

El-Nachef, Claudia ^{[1
]}

Bajaj, Kiran ^{[1
]}

Al-Youbi, Abdulrahman O. ^{[2
]}

Oliferenko, Alexander ^{[1
]}

Katritzky, Alan R. ^{[1
,2
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 80卷 / 06期

关键词：

acyl migration; ligation; molecular modeling; peptide; GLYCOPEPTIDE LIGATION; STAUDINGER LIGATION; PEPTIDE; SCOPE; DIMER;

D O I：

10.1111/cbdd.12053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unprotected S-acylated cysteine isopeptides containing alpha-, beta- or gamma-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.

引用

页码：821 / 827

页数：7

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