Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm

被引：197

作者：

Abumrad, N ^{[1
]}

Coburn, C ^{[1
]}

Ibrahimi, A ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1441卷 / 01期

关键词：

D O I：

10.1016/S1388-1981(99)00137-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-chain fatty acids can transfer passively across mammalian cell membranes. However, under physiological conditions of low fatty acid to albumin ratios in the circulation, the major fraction of uptake appears to be mediated by a saturable, protein-facilitated component. A simple diffusion process becomes significant at high molar ratios of fatty acid to albumin as the concentration of free fatty acid in solution is increased. Identification of the mammalian membrane fatty acid transporter(s) has been the focus of active investigation by several research groups. In this review we discuss three candidate proteins: FABPm, FAT/CD36 and FATP which have been cloned and are currently being characterized. Recent evidence arguing for an important role of the fatty acid transport step in general metabolism and linking these proteins to physiologic or metabolic abnormalities is described. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：4 / 13

页数：10

共 111 条

[1]

Abumrad N, 1998, J LIPID RES, V39, P2309

[2]

ABUMRAD NA, 1984, J BIOL CHEM, V259, P8945

[3]

ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665

[4]

ABUMRAD NA, 1981, J BIOL CHEM, V256, P9183

[5] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].

Acton, S ;

Rigotti, A ;

Landschulz, KT ;

Xu, SZ ;

Hobbs, HH ;

Krieger, M .

SCIENCE, 1996, 271 (5248) :518-520

[6]

ACTON SL, 1994, J BIOL CHEM, V269, P21003

[7] Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats [J].

Aitman, TJ ;

Glazier, AM ;

Wallace, CA ;

Cooper, LD ;

Norsworthy, PJ ;

Wahid, FN ;

Al-Majali, KM ;

Trembling, PM ;

Mann, CJ ;

Shoulders, CC ;

Graf, D ;

St Lezin, E ;

Kurtz, TW ;

Kren, V ;

Pravenec, M ;

Ibrahimi, A ;

Abumrad, NA ;

Stanton, LW ;

Scott, J .

NATURE GENETICS, 1999, 21 (01) :76-83

[8]

AMRI EZ, 1991, J LIPID RES, V32, P1449

[9] CLONING OF A PROTEIN THAT MEDIATES TRANSCRIPTIONAL EFFECTS OF FATTY-ACIDS IN PREADIPOCYTES - HOMOLOGY TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS [J].

AMRI, EZ ;

BONINO, F ;

AILHAUD, G ;

ABUMRAD, NA ;

GRIMALDI, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (05) :2367-2371

[10] FATTY-ACIDS INHIBIT APICAL MEMBRANE CHLORIDE CHANNELS IN AIRWAY EPITHELIA [J].

ANDERSON, MP ;

WELSH, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7334-7338

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