Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis

被引：41

作者：

Strelow, LI

Leib, DA

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT OPHTHALMOL & VISUAL SCI,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 08期

关键词：

D O I：

10.1128/JVI.70.8.5665-5667.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpes simplex virus type 1 virion host shutoff protein has four domains whose sequences are conserved only among neurotropic herpesviruses. Mutant viruses with 29- and S1-amino-acid deletions in domains III and IV but outside of the domain required for interaction with VP16 were generated. The mutants failed to induce cellular RNA degradation and showed impaired virulence in mice. Domains III and IV are therefore required for both shutoff and virulence.

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页码：5665 / 5667

页数：3

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