Risk factors for Candida tropicalis fungemia in patients with cancer

被引：120

作者：

Kontoyiannis, DP ^{[1
]}

Vaziri, I ^{[1
]}

Hanna, HA ^{[1
]}

Boktour, M ^{[1
]}

Thornby, J ^{[1
]}

Hachem, R ^{[1
]}

Bodey, GP ^{[1
]}

Raad, II ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 33卷 / 10期

关键词：

D O I：

10.1086/323812

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P=.0006), prolonged neutropenia (P=.03), and a positive blood culture for more days (P = .02). The 2 groups did not differ with regard to baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of catheter-associated fungemia, or response to antifungals. In multivariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P=.02), previous neutropenia (P=.002), and a longer stay in the intensive care unit during the infectious episode (P=.01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P=.05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia.

引用

页码：1676 / 1681

页数：6

共 29 条

[1] Candida krusei fungemia -: An escalating serious infection in immunocompromised patients [J].