Breastfeeding Protects against Current Asthma up to 6 Years of Age

被引:76
作者
Silvers, Karen M. [1 ]
Frampton, Chris M. [2 ]
Wickens, Kristin [3 ]
Pattemore, Philip K. [1 ]
Ingham, Tristram [3 ]
Fishwick, David [4 ]
Crane, Julian [3 ]
Town, G. Ian [5 ]
Epton, Michael J. [2 ,6 ]
机构
[1] Univ Otago, Sch Med & Hlth Sci, Dept Paediat, Christchurch, New Zealand
[2] Univ Otago, Sch Med & Hlth Sci, Dept Med, Christchurch, New Zealand
[3] Univ Otago, Sch Med & Hlth Sci, Dept Med, Wellington Asthma Res Grp, Wellington, New Zealand
[4] Univ Sheffield, Ctr Workpl Hlth, Sheffield, S Yorkshire, England
[5] Univ Canterbury, Christchurch 1, New Zealand
[6] Christchurch Hosp, Canterbury Resp Res Grp, Christchurch, New Zealand
关键词
BIRTH COHORT; CHILDREN; ALLERGY; RISK; ATOPY; CHILDHOOD; WHEEZE;
D O I
10.1016/j.jpeds.2011.11.055
中图分类号
R72 [儿科学];
学科分类号
100202 [儿科学];
摘要
Objective To investigate the effects of breastfeeding on wheezing and current asthma in children 2 to 6 years of age. Study design Infants (n = 1105) were enrolled in a prospective birth cohort in New Zealand. Detailed information about infant feeding was collected using questionnaires administered at birth and at 3, 6, and 15 months. From this, durations of exclusive and any breastfeeding were calculated. Information about wheezing and current asthma was collected at 2, 3, 4, 5, and 6 years. Logistic regression was used to model associations between breastfeeding and outcomes with and without adjustment for confounders. Results After adjustment for confounders, each month of exclusive breastfeeding was associated with significant reductions in current asthma from 2 to 6 years (all, P < .03). Current asthma at 2, 3, and 4 years was also reduced by each month of any breastfeeding (all, P < .005). In atopic children, exclusive breastfeeding for >= 3 months reduced current asthma at ages 4, 5, and 6 by 62%, 55%, and 59%, respectively. Conclusion Breastfeeding, particularly exclusive breastfeeding, protects against current asthma up to 6 years. Although exclusive breastfeeding reduced risk of current asthma in all children to age 6, the degree of protection beyond 3 years was more pronounced in atopic children. (J Pediatr 2012;square:square-square).
引用
收藏
页码:991 / 996.e1
页数:7
相关论文
共 17 条
[1]
Breastfeeding does not increase the risk of asthma at 14 years [J].
Burgess, SW ;
Dakin, CJ ;
O'Callaghan, MJ .
PEDIATRICS, 2006, 117 (04) :E787-E792
[2]
Prospective study of breast-feeding in relation to wheeze, atopy, and bronchial hyperresponsiveness in the Avon Longitudinal Study of Parents and Children (ALSPAC) [J].
Elliott, Leslie ;
Henderson, John ;
Northstone, Kate ;
Chiu, Grace Y. ;
Dunson, David ;
London, Stephanie J. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 122 (01) :49-54
[3]
The New Zealand Asthma and Allergy Cohort Study (NZA2CS):: Assembly, demographics and investigations [J].
Epton, Michael J. ;
Town, George I. ;
Ingham, Tristram ;
Wickens, Kristin ;
Fishwick, David ;
Crane, Julian .
BMC PUBLIC HEALTH, 2007, 7
[4]
Breast-feeding and the risk of bronchial asthma in childhood: A systematic review with meta-analysis of prospective studies [J].
Gdalevich, M ;
Mimouni, D ;
Mimouni, M .
JOURNAL OF PEDIATRICS, 2001, 139 (02) :261-266
[5]
Ip Stanley, 2007, Evid Rep Technol Assess (Full Rep), P1
[6]
*JOINT TASK FORC P, 1995, J ALLERGY CLIN IMMUN, V96, P707
[7]
Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial [J].
Kramer, Michael S. ;
Matush, Lidia ;
Vanilovich, Irina ;
Platt, Robert ;
Bogdanovich, Natalia ;
Sevkovskaya, Zinaida ;
Dzikovich, Irina ;
Shishko, Gyorgy ;
MazerS, Bruce .
BMJ-BRITISH MEDICAL JOURNAL, 2007, 335 (7624) :815-B818
[8]
Breast-feeding reduces the risk of asthma during the first 4 years of life [J].
Kull, I ;
Almqvist, C ;
Lilja, G ;
Pershagen, G ;
Wickman, M .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (04) :755-760
[9]
Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy [J].
Mandhane, Piush J. ;
Greene, Justina M. ;
Sears, Malcolm R. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (06) :1359-1366
[10]
INFLUENCE OF SKIN PRICK TEST CRITERIA ON ESTIMATION OF PREVALENCE AND INCIDENCE OF ALLERGIC SENSITIZATION IN CHILDREN [J].
MEINERT, R ;
FRISCHER, T ;
KARMAUS, W ;
KUEHR, J .
ALLERGY, 1994, 49 (07) :526-532