Ageing - A message from the gonads

被引:4
作者
Riddle, DL [1 ]
机构
[1] Univ Missouri, Program Mol Biol, Columbia, MO 65211 USA
[2] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA
关键词
D O I
10.1038/20557
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Theories of ageing have it that there may be trade-offs between an individual's reproductive success and its life span. Work with the nematode wormCaenorhabditis elegansis revealing the mechanisms behind that principle — the latest studies show how signals from the worm's reproductive system influence its longevity.
引用
收藏
页码:308 / 309
页数:2
相关论文
共 11 条
[1]  
Gems D, 1998, GENETICS, V150, P129
[2]   Signals from the reproductive system regulate the lifespan of C-elegans [J].
Hsin, H ;
Kenyon, C .
NATURE, 1999, 399 (6734) :362-366
[3]   A C-ELEGANS MUTANT THAT LIVES TWICE AS LONG AS WILD-TYPE [J].
KENYON, C ;
CHANG, J ;
GENSCH, E ;
RUDNER, A ;
TABTIANG, R .
NATURE, 1993, 366 (6454) :461-464
[4]   daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans [J].
Kimura, KD ;
Tissenbaum, HA ;
Liu, YX ;
Ruvkun, G .
SCIENCE, 1997, 277 (5328) :942-946
[5]   NON-AGING DEVELOPMENTAL VARIANT OF CAENORHABDITIS-ELEGANS [J].
KLASS, M ;
HIRSH, D .
NATURE, 1976, 260 (5551) :523-525
[6]  
LARSEN PL, 1995, GENETICS, V139, P1567
[7]   daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans [J].
Lin, K ;
Dorman, JB ;
Rodan, A ;
Kenyon, C .
SCIENCE, 1997, 278 (5341) :1319-1322
[8]   The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C-elegans [J].
Ogg, S ;
Paradis, S ;
Gottlieb, S ;
Patterson, GI ;
Lee, L ;
Tissenbaum, HA ;
Ruvkun, G .
NATURE, 1997, 389 (6654) :994-999
[9]  
Riddle D. L., 1997, C ELEGANS, P739
[10]  
Rose M. R., 1994, Evolutionary biology of aging