Eu(fod)3-catalyzed solid-phase [4+2] heterocycloadditions:: an efficient asymmetric process in catalyst-recycling conditions

被引：19

作者：

Dujardin, G ^{[1
]}

Leconte, S ^{[1
]}

Coutable, L ^{[1
]}

Brown, E ^{[1
]}

机构：

[1] Fac Sci, CNRS, Organ Synth Lab, F-72085 Le Mans 9, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 50期

关键词：

hetero Diels-Alder reactions; solid-phase synthesis; chiral dienophile; reusable catalyst;

D O I：

10.1016/S0040-4039(01)01921-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under Eu(fod)(3)-catalyzed conditions, the endo-selective hetero Diels-Alder reaction of (S)-(+)-O-vinyl mandelate with Wang-supported benzylidenepyruvate occurred with a 93/7 facial selectivity that compares well with those observed in solution. In addition, the solid-phase sequence allowed an unprecedented reuse of the catalyst in the presence of excess dienophile in solution. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8849 / 8852

页数：4

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